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- W2063066831 abstract "In addition to their potential for replacing damaged and diseased tissues by differentiating into tissue-specific cells, mesenchymal stem cells (MSCs) have been found to interact closely with immune cells, such as lymphocytes. In this review, we will discuss current research regarding the immunomodulatory properties of MSCs and the effects of lymphocytes on MSCs. We will suggest how these findings could be translated to potential clinical treatment. MSCs can regulate immune response by inducing activated T-cell apoptosis through the FAS ligand (FASL)/FAS-mediated death pathway via cell-cell contact, leading to up-regulation of regulatory T-cells (Tregs), which ultimately results in immune tolerance. Conversely, lymphocytes can impair survival and osteogenic differentiation of implanted MSCs by secreting the pro-inflammatory cytokines IFN-γ and TNF-α and/or through the FASL/FAS-mediated death pathway, thereby negatively affecting MSC-mediated tissue regeneration. One novel strategy to improve MSC-based tissue engineering involves the reduction of IFN-γ and TNF-α concentration by systemic infusion of Tregs or local application of aspirin. Further understanding of the mechanisms underlying the interplay between lymphocytes and MSCs may be helpful in the development of promising approaches to improve cell-based regenerative medicine and immune therapies." @default.
- W2063066831 created "2016-06-24" @default.
- W2063066831 creator A5007256280 @default.
- W2063066831 creator A5062097448 @default.
- W2063066831 creator A5082083166 @default.
- W2063066831 date "2012-09-17" @default.
- W2063066831 modified "2023-10-17" @default.
- W2063066831 title "Interplay between Mesenchymal Stem Cells and Lymphocytes" @default.
- W2063066831 cites W1968159361 @default.
- W2063066831 cites W1968255500 @default.
- W2063066831 cites W1968628080 @default.
- W2063066831 cites W1973076028 @default.
- W2063066831 cites W1979043688 @default.
- W2063066831 cites W1981787940 @default.
- W2063066831 cites W1982408656 @default.
- W2063066831 cites W1988477032 @default.
- W2063066831 cites W1989632074 @default.
- W2063066831 cites W1997470313 @default.
- W2063066831 cites W2003096272 @default.
- W2063066831 cites W2003566728 @default.
- W2063066831 cites W2003996125 @default.
- W2063066831 cites W2007624518 @default.
- W2063066831 cites W2014646480 @default.
- W2063066831 cites W2016662872 @default.
- W2063066831 cites W2019269134 @default.
- W2063066831 cites W2019495971 @default.
- W2063066831 cites W2020114480 @default.
- W2063066831 cites W2023849906 @default.
- W2063066831 cites W2024070040 @default.
- W2063066831 cites W2024326908 @default.
- W2063066831 cites W2024579131 @default.
- W2063066831 cites W2024971445 @default.
- W2063066831 cites W2028239901 @default.
- W2063066831 cites W2030927418 @default.
- W2063066831 cites W2033230449 @default.
- W2063066831 cites W2034706779 @default.
- W2063066831 cites W2034913592 @default.
- W2063066831 cites W2035976926 @default.
- W2063066831 cites W2044294389 @default.
- W2063066831 cites W2047604189 @default.
- W2063066831 cites W2051297632 @default.
- W2063066831 cites W2053798613 @default.
- W2063066831 cites W2053984526 @default.
- W2063066831 cites W2055400697 @default.
- W2063066831 cites W2056281529 @default.
- W2063066831 cites W2057023851 @default.
- W2063066831 cites W2057887260 @default.
- W2063066831 cites W2058146698 @default.
- W2063066831 cites W2058839233 @default.
- W2063066831 cites W2058906612 @default.
- W2063066831 cites W2060167203 @default.
- W2063066831 cites W2064919073 @default.
- W2063066831 cites W2070393128 @default.
- W2063066831 cites W2074624875 @default.
- W2063066831 cites W2078489918 @default.
- W2063066831 cites W2080137511 @default.
- W2063066831 cites W2080431262 @default.
- W2063066831 cites W2087353148 @default.
- W2063066831 cites W2088500471 @default.
- W2063066831 cites W2093651836 @default.
- W2063066831 cites W2095666785 @default.
- W2063066831 cites W2097642599 @default.
- W2063066831 cites W2097811455 @default.
- W2063066831 cites W2098863391 @default.
- W2063066831 cites W2102726602 @default.
- W2063066831 cites W2106072740 @default.
- W2063066831 cites W2106117542 @default.
- W2063066831 cites W2113933847 @default.
- W2063066831 cites W2115240957 @default.
- W2063066831 cites W2116864112 @default.
- W2063066831 cites W2119801904 @default.
- W2063066831 cites W2120651904 @default.
- W2063066831 cites W2122659446 @default.
- W2063066831 cites W2125442794 @default.
- W2063066831 cites W2130516299 @default.
- W2063066831 cites W2131004666 @default.
- W2063066831 cites W2133375451 @default.
- W2063066831 cites W2136192456 @default.
- W2063066831 cites W2144224215 @default.
- W2063066831 cites W2144268541 @default.
- W2063066831 cites W2147061961 @default.
- W2063066831 cites W2148562877 @default.
- W2063066831 cites W2154088932 @default.
- W2063066831 cites W2155044423 @default.
- W2063066831 cites W2157155777 @default.
- W2063066831 cites W2158837806 @default.
- W2063066831 cites W2159079511 @default.
- W2063066831 cites W2159314490 @default.
- W2063066831 cites W2159358845 @default.
- W2063066831 cites W2167992899 @default.
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- W2063066831 doi "https://doi.org/10.1177/0022034512460404" @default.
- W2063066831 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3490280" @default.
- W2063066831 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22988011" @default.
- W2063066831 hasPublicationYear "2012" @default.
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