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- W2063067967 abstract "In the present study was made to develop a suitable matrix type transdermal patch of Candesartan Cilexetil, using blends of t wo different types of polymeric combinations viz. HPMC K100 and Eudragit RL100 prepared formulations were subjected to various p hysiochemical evaluation tests like moisture content loss, moisture absorption, flatness to study the stability of the formulations, in vitro dissolution was performed to determine the amount of Candesartan present in the patches. Drug excipient interactio n studies were carried out using Fourier transform infrared (FTIR) spectroscopy technique. The in vitro release of the drug from the formulations was studied using commercial semi permeable membrane. All the formulations were found to be suitab le for formu lating in terms of physiochemical characteristics and there was no notification in significant interaction between the drug and polymer used. In vitro dissolution data showed that formulation of F11 showed faster release of drug than the F14 formulations d uring dissolution studies. Skin irritation studies revealed that the batch containing HPMCK100 - Eudragit RL100 has no erythema and edema. Based on the observation, we can reveal that HPMCK100 - eudragit RL100 polymers are better suited for the development of Candesartan cilexetil transdermal patches." @default.
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- W2063067967 date "2013-07-05" @default.
- W2063067967 modified "2023-10-10" @default.
- W2063067967 title "FORMULATION AND IN-VITRO EVALUATION OF TRANSDERMAL FILMS OF AN ANTI HYPERTENSIVE DRUG" @default.
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- W2063067967 doi "https://doi.org/10.7897/2230-8407.04615" @default.
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