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- W2063068910 abstract "Ion-sensitive microelectrodes were used to study the behavior of extracellular ions in rat sciatic nerve during and following activity. Nerve stimulation produced increases in [K+]o that were dependent upon the frequency and duration of stimulation; no change in extracellular pH occurred with stimulation. Increases in [K+]o dependent on axonal discharge since they were blocked by inhibiting sodium channels with tetrodotoxin. At 22°C, stimulation could induce increases in [K+]o of several mM; at 36°C, stimulation rarely produced increases in [K+]o greater than 1mM. Stimulated increases in [K+]o dissipated very slowly (i.e. t1/2 = 50–100s) and the rate of dissipation was not significantly affected by anoxia, changes in temperature, changes in extracellular pH, or the application of a blocker of Na+, K+-ATPase (ouabain) or a K+ channel blocker (Ba2+). In comparison to the central nervous system, neural activity in rat sciatic nerve produced smaller increases in [K+]o and these increases dissipated much more slowly. The primary mechanism of K+ dissipation appeared to be diffusion, probably facilitated by the larger extracellular space in peripheral nerve compared to the central nervous system, but impeded by diffusion barriers imposed by the blood-nerve barrier." @default.
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- W2063068910 date "1991-06-01" @default.
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- W2063068910 title "Characteristics of activity-dependent potassium accumulation in mammalian peripheral nerve in vitro" @default.
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- W2063068910 doi "https://doi.org/10.1016/0006-8993(91)90666-j" @default.
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