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- W2063071041 abstract "Host cell factor-1(HCF-1) was first discovered as a cellular cofactor in the VP16-induced complex, a multi-protein DNA complex that forms on immediate early gene promoters of herpes simplex virus (HSV) to activate viral gene transcription. Subsequent research has revealed HCF-1 to be an abundant chromatin-associated protein that regulates various stages of the cell cycle. Recent reports show that HCF-1 interacts with diverse E2F proteins to induce cell-cycle-specific transcription. HCF-1 can act as a scaffold to a variety of histone-modifying proteins and these HCF-1-E2F-containing multi-protein complexes can bring about context-dependent activation or repression of transcription. In this review we examine the diversity of HCF-E2F interactions and the variety of multi-protein complexes it occurs in, to influence the local chromatin landscape at the E2F-promoters." @default.
- W2063071041 created "2016-06-24" @default.
- W2063071041 creator A5080419874 @default.
- W2063071041 creator A5081889503 @default.
- W2063071041 date "2012-07-01" @default.
- W2063071041 modified "2023-10-13" @default.
- W2063071041 title "Role of Host Cell Factor-1 in cell cycle regulation." @default.
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- W2063071041 doi "https://doi.org/10.4161/trns.20711" @default.
- W2063071041 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3654768" @default.
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