FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2063073504> ?p ?o ?g. }

• W2063073504 endingPage "1094" @default.
• W2063073504 startingPage "1085" @default.
• W2063073504 abstract "After injury to the CNS, the anatomical organization of the tissue is disrupted, posing a barrier to the regeneration of axons. Meningeal cells, a central participant in the CNS tissue response to injury, migrate into the core of the wound site in an unorganized fashion and deposit a disorganized extracellular matrix (ECM) that produces a nonpermissive environment. Previous work in our laboratory has shown that the presentation of nanometer-scale topographic cues to these cells influences their morphological, cytoskeletal, and secreted ECM alignment. In the present study, we provided similar environmental cues to meningeal cells and examined the ability of the composite construct to influence dorsal root ganglion regeneration in vitro. When grown on control surfaces of meningeal cells lacking underlying topographic cues, there was no bias in neurite outgrowth. In contrast, when grown on monolayers of meningeal cells with underlying nanometer-scale topography, neurite outgrowth length was greater and was directed parallel to the underlying surface topography even though there exists an intervening meningeal cell layer. The observed outgrowth was significantly longer than on laminin-coated surfaces, which are considered to be the optimal substrata for promoting outgrowth of dorsal root ganglion neurons in culture. These results suggest that the nanometer-level surface finish of an implanted biomaterial may be used to organize the encapsulation tissue that accompanies the implantation of materials into the CNS. It furthermore suggests a simple approach for improving bridging materials for repair of nerve tracts or for affecting cellular organization at a device–tissue interface." @default.
• W2063073504 created "2016-06-24" @default.
• W2063073504 creator A5000424501 @default.
• W2063073504 creator A5044009382 @default.
• W2063073504 creator A5077270806 @default.
• W2063073504 date "2005-07-01" @default.
• W2063073504 modified "2023-09-27" @default.
• W2063073504 title "Directional Neurite Outgrowth Is Enhanced by Engineered Meningeal Cell-Coated Substrates" @default.
• W2063073504 cites W1539015351 @default.
• W2063073504 cites W1586855301 @default.
• W2063073504 cites W1635850624 @default.
• W2063073504 cites W1817134384 @default.
• W2063073504 cites W1826719783 @default.
• W2063073504 cites W1965381196 @default.
• W2063073504 cites W1967852720 @default.
• W2063073504 cites W1970805231 @default.
• W2063073504 cites W1981739047 @default.
• W2063073504 cites W1986574486 @default.
• W2063073504 cites W1989826449 @default.
• W2063073504 cites W1997211671 @default.
• W2063073504 cites W2005416260 @default.
• W2063073504 cites W2009097826 @default.
• W2063073504 cites W2009860522 @default.
• W2063073504 cites W2013035816 @default.
• W2063073504 cites W2031698742 @default.
• W2063073504 cites W2033797242 @default.
• W2063073504 cites W2036713307 @default.
• W2063073504 cites W2038594557 @default.
• W2063073504 cites W2040021594 @default.
• W2063073504 cites W2040569779 @default.
• W2063073504 cites W2040840739 @default.
• W2063073504 cites W2044301802 @default.
• W2063073504 cites W2050284658 @default.
• W2063073504 cites W2052929840 @default.
• W2063073504 cites W2053623203 @default.
• W2063073504 cites W2053878919 @default.
• W2063073504 cites W2056884254 @default.
• W2063073504 cites W2061354480 @default.
• W2063073504 cites W2065318894 @default.
• W2063073504 cites W2066768537 @default.
• W2063073504 cites W2067401348 @default.
• W2063073504 cites W2067673651 @default.
• W2063073504 cites W2067930568 @default.
• W2063073504 cites W2069193576 @default.
• W2063073504 cites W2074249396 @default.
• W2063073504 cites W2075312842 @default.
• W2063073504 cites W2084099920 @default.
• W2063073504 cites W2084123923 @default.
• W2063073504 cites W2086037466 @default.
• W2063073504 cites W2089277163 @default.
• W2063073504 cites W2092387725 @default.
• W2063073504 cites W2093355367 @default.
• W2063073504 cites W2097325660 @default.
• W2063073504 cites W2097530133 @default.
• W2063073504 cites W2102930266 @default.
• W2063073504 cites W2145928890 @default.
• W2063073504 cites W2147149841 @default.
• W2063073504 cites W2148304597 @default.
• W2063073504 cites W2150526232 @default.
• W2063073504 cites W2150596913 @default.
• W2063073504 cites W2166149868 @default.
• W2063073504 cites W2166779985 @default.
• W2063073504 cites W223795620 @default.
• W2063073504 cites W2883272313 @default.
• W2063073504 cites W4233568782 @default.
• W2063073504 doi "https://doi.org/10.1089/ten.2005.11.1085" @default.
• W2063073504 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16144444" @default.
• W2063073504 hasPublicationYear "2005" @default.
• W2063073504 type Work @default.
• W2063073504 sameAs 2063073504 @default.
• W2063073504 citedByCount "36" @default.
• W2063073504 countsByYear W20630735042012 @default.
• W2063073504 countsByYear W20630735042013 @default.
• W2063073504 countsByYear W20630735042014 @default.
• W2063073504 countsByYear W20630735042015 @default.
• W2063073504 countsByYear W20630735042016 @default.
• W2063073504 countsByYear W20630735042020 @default.
• W2063073504 countsByYear W20630735042022 @default.
• W2063073504 crossrefType "journal-article" @default.
• W2063073504 hasAuthorship W2063073504A5000424501 @default.
• W2063073504 hasAuthorship W2063073504A5044009382 @default.
• W2063073504 hasAuthorship W2063073504A5077270806 @default.
• W2063073504 hasConcept C105702510 @default.
• W2063073504 hasConcept C113246987 @default.
• W2063073504 hasConcept C136229726 @default.
• W2063073504 hasConcept C140530291 @default.
• W2063073504 hasConcept C169760540 @default.
• W2063073504 hasConcept C171056886 @default.
• W2063073504 hasConcept C185592680 @default.
• W2063073504 hasConcept C189165786 @default.
• W2063073504 hasConcept C202751555 @default.
• W2063073504 hasConcept C2776281502 @default.
• W2063073504 hasConcept C2779814568 @default.
• W2063073504 hasConcept C49892992 @default.
• W2063073504 hasConcept C55493867 @default.
• W2063073504 hasConcept C71924100 @default.
• W2063073504 hasConcept C86803240 @default.
• W2063073504 hasConcept C95444343 @default.

• next