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- W2063081323 abstract "This work investigates the role of N- to C- termini coupling in the folding transition of small, single domain proteins via extensive Monte Carlo simulations of both lattice and off-lattice models. The reported results provide compelling evidence that the existence of native interactions between the terminal regions of the polypeptide chain (i.e. termini coupling) is a major determinant of the height of the free energy barrier that separates the folded from the denatured state in a two-state folding transition, therefore being a critical modulator of protein folding rates and thermodynamic cooperativity. We further report that termini interactions are able to substantially modify the kinetic behavior dictated by the full set of native interactions. Indeed, a native structure of high contact order with switched-off termini-interactions actually folds faster than its circular permutant of lowest CO." @default.
- W2063081323 created "2016-06-24" @default.
- W2063081323 creator A5032889484 @default.
- W2063081323 creator A5052906833 @default.
- W2063081323 creator A5061571670 @default.
- W2063081323 date "2015-01-01" @default.
- W2063081323 modified "2023-10-15" @default.
- W2063081323 title "How determinant is N-terminal to C-terminal coupling for protein folding?" @default.
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- W2063081323 cites W1988655344 @default.
- W2063081323 cites W1989756489 @default.
- W2063081323 cites W1990771740 @default.
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- W2063081323 doi "https://doi.org/10.1039/c4cp05178e" @default.
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- W2063081323 hasPublicationYear "2015" @default.
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