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- W2063084911 abstract "Temporin A is a small, basic, highly hydrophobic, antibacterial peptide found in the skin of the European red frog, Rana temporaria . It was synthesized twice by the FastMoc solid phase method using amino acids protected at the N α ‐position with either 9‐fluorenylmethoxycarbonyl or 2‐(4‐nitrophenylsulfonyl)ethoxycarbonyl. The syntheses of temporin A demonstrates the difference between 2‐(4‐nitrophenylsulfonyl)ethoxycarbonyl and 9‐fluorenylmethoxycarbonyl amino acids. The purified peptide showed also antibacterial activity against clinically important Gram‐positive bacteria. It was found to have a moderately good activity against both methicillin resistant and sensitive strains of Staphylococcus aureus , but a weaker activity against vancomycin resistant strains of Enterococcus faecium ." @default.
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- W2063084911 date "1999-04-23" @default.
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- W2063084911 title "Comparison of synthesis and antibacterial activity of temporin A" @default.
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- W2063084911 doi "https://doi.org/10.1016/s0014-5793(99)00406-8" @default.
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