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- W2063085024 abstract "Purpose of review Receptor for advanced glycation endproducts (RAGE) is a multiligand receptor of the immunoglobulin superfamily, which binds not only to advanced glycation endproducts, but also to high-mobility group box-1, S100/calgranulins, amyloid fibrils, and lipopolysaccharide. We discuss the pathophysiological role of RAGE in both diabetic and nondiabetic progressive renal diseases, and its potential use for therapeutic interventions in these devastating disorders. Recent findings Although initial studies about RAGE focused on diabetic nephropathy, a number of recent findings have revealed that RAGE also actively participates in the pathogenesis of nondiabetic progressive renal diseases, including hypertensive nephropathy, obesity-related glomerulopathy, lupus nephritis, autosomal dominant polycystic kidney disease, renal amyloidosis, and septic acute kidney injury. Furthermore, blocking the RAGE by a neutralizing antibody or genetic deletion of RAGE was found to prevent the development and progression of various renal disorders. Summary The interaction of several RAGE ligands with RAGE plays a role in a broad range of progressive kidney diseases. The blockade of the various RAGE ligands–RAGE interactions might be a novel therapeutic strategy for preventing the development and progression of numerous progressive kidney diseases." @default.
- W2063085024 created "2016-06-24" @default.
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- W2063085024 date "2015-01-01" @default.
- W2063085024 modified "2023-10-04" @default.
- W2063085024 title "Receptor for advanced glycation endproducts and progressive kidney disease" @default.
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- W2063085024 doi "https://doi.org/10.1097/mnh.0000000000000091" @default.
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