FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2063093896> ?p ?o ?g. }

• W2063093896 endingPage "1268" @default.
• W2063093896 startingPage "1262" @default.
• W2063093896 abstract "OBJECTIVE Acute, short-term hyperglycemia enhances high shear stress–induced platelet activation in type 2 diabetes. Several observations suggest that platelets in type 2 diabetes are resistant to inhibition by aspirin. Our aim was to assess comparatively the effect of aspirin, a nitric oxide–donating agent (NCX 4016), their combination, or placebo on platelet activation induced by acute hyperglycemia in type 2 diabetes. RESEARCH DESIGN AND METHODS In a double-blind, placebo-controlled, randomized trial, 40 type 2 diabetic patients were allocated to 100 mg aspirin once daily, 800 mg NCX 4016 b.i.d., both of them, or placebo for 15 days. On day 15, 1 h after the morning dose, a 4-h hyperglycemic clamp (plasma glucose 13.9 mmol/l) was performed, and blood samples were collected before and immediately after it for platelet activation and cyclooxygenase-1 (COX-1) inhibition studies. RESULTS Acute hyperglycemia enhanced shear stress–induced platelet activation in placebo-treated patients (basal closure time 63 ± 7.1 s, after hyperglycemia 49.5 ± 1.4 s, −13.5 ± 6.3 s, P &lt; 0.048). Pretreatment with aspirin, despite full inhibition of platelet COX-1, did not prevent it (−12.7 ± 6.9 s, NS vs. placebo). On the contrary, pretreatment with the NO donor NCX 4016, alone or in combination with aspirin, suppressed platelet activation induced by acute hyperglycemia (NCX 4016 +10.5 ± 8.3 s; NCX 4016 plus aspirin: +12.0 ± 10.7 s, P &lt; 0.05 vs. placebo for both). Other parameters of shear stress–dependent platelet activation were also more inhibited by NCX 4016 than by aspirin, despite lesser inhibition of COX-1. CONCLUSIONS Acute hyperglycemia-induced enhancement of platelet activation is resistant to aspirin; a NO-donating agent suppresses it. Therapeutic approaches aiming at a wider platelet inhibitory action than that exerted by aspirin may prove useful in patients with type 2 diabetes." @default.
• W2063093896 created "2016-06-24" @default.
• W2063093896 creator A5003292078 @default.
• W2063093896 creator A5013957595 @default.
• W2063093896 creator A5017420010 @default.
• W2063093896 creator A5053039930 @default.
• W2063093896 creator A5057323309 @default.
• W2063093896 creator A5068865403 @default.
• W2063093896 creator A5079075203 @default.
• W2063093896 creator A5089202679 @default.
• W2063093896 date "2010-03-18" @default.
• W2063093896 modified "2023-09-23" @default.
• W2063093896 title "Hyperglycemia-Induced Platelet Activation in Type 2 Diabetes Is Resistant to Aspirin but Not to a Nitric Oxide–Donating Agent" @default.
• W2063093896 cites W107715711 @default.
• W2063093896 cites W1480729244 @default.
• W2063093896 cites W1971377175 @default.
• W2063093896 cites W1975065156 @default.
• W2063093896 cites W2001452537 @default.
• W2063093896 cites W2023429077 @default.
• W2063093896 cites W2023835550 @default.
• W2063093896 cites W2024352468 @default.
• W2063093896 cites W2029655841 @default.
• W2063093896 cites W2030851349 @default.
• W2063093896 cites W2031440396 @default.
• W2063093896 cites W2032347575 @default.
• W2063093896 cites W2045851208 @default.
• W2063093896 cites W2046152872 @default.
• W2063093896 cites W2090824142 @default.
• W2063093896 cites W2090978392 @default.
• W2063093896 cites W2096755690 @default.
• W2063093896 cites W2102182741 @default.
• W2063093896 cites W2104599604 @default.
• W2063093896 cites W2120704605 @default.
• W2063093896 cites W2131973909 @default.
• W2063093896 cites W2144125787 @default.
• W2063093896 cites W2147722226 @default.
• W2063093896 cites W2156457325 @default.
• W2063093896 cites W2404130138 @default.
• W2063093896 cites W294423481 @default.
• W2063093896 cites W4244537139 @default.
• W2063093896 doi "https://doi.org/10.2337/dc09-2013" @default.
• W2063093896 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2875435" @default.
• W2063093896 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20299485" @default.
• W2063093896 hasPublicationYear "2010" @default.
• W2063093896 type Work @default.
• W2063093896 sameAs 2063093896 @default.
• W2063093896 citedByCount "42" @default.
• W2063093896 countsByYear W20630938962012 @default.
• W2063093896 countsByYear W20630938962013 @default.
• W2063093896 countsByYear W20630938962014 @default.
• W2063093896 countsByYear W20630938962015 @default.
• W2063093896 countsByYear W20630938962016 @default.
• W2063093896 countsByYear W20630938962017 @default.
• W2063093896 countsByYear W20630938962018 @default.
• W2063093896 countsByYear W20630938962019 @default.
• W2063093896 countsByYear W20630938962020 @default.
• W2063093896 countsByYear W20630938962021 @default.
• W2063093896 countsByYear W20630938962022 @default.
• W2063093896 countsByYear W20630938962023 @default.
• W2063093896 crossrefType "journal-article" @default.
• W2063093896 hasAuthorship W2063093896A5003292078 @default.
• W2063093896 hasAuthorship W2063093896A5013957595 @default.
• W2063093896 hasAuthorship W2063093896A5017420010 @default.
• W2063093896 hasAuthorship W2063093896A5053039930 @default.
• W2063093896 hasAuthorship W2063093896A5057323309 @default.
• W2063093896 hasAuthorship W2063093896A5068865403 @default.
• W2063093896 hasAuthorship W2063093896A5079075203 @default.
• W2063093896 hasAuthorship W2063093896A5089202679 @default.
• W2063093896 hasBestOaLocation W20630938961 @default.
• W2063093896 hasConcept C126322002 @default.
• W2063093896 hasConcept C134018914 @default.
• W2063093896 hasConcept C142724271 @default.
• W2063093896 hasConcept C181199279 @default.
• W2063093896 hasConcept C185592680 @default.
• W2063093896 hasConcept C204787440 @default.
• W2063093896 hasConcept C27081682 @default.
• W2063093896 hasConcept C2777180221 @default.
• W2063093896 hasConcept C2777628954 @default.
• W2063093896 hasConcept C2779689624 @default.
• W2063093896 hasConcept C3018697912 @default.
• W2063093896 hasConcept C519581460 @default.
• W2063093896 hasConcept C55493867 @default.
• W2063093896 hasConcept C555293320 @default.
• W2063093896 hasConcept C71924100 @default.
• W2063093896 hasConcept C89560881 @default.
• W2063093896 hasConcept C90924648 @default.
• W2063093896 hasConcept C98274493 @default.
• W2063093896 hasConceptScore W2063093896C126322002 @default.
• W2063093896 hasConceptScore W2063093896C134018914 @default.
• W2063093896 hasConceptScore W2063093896C142724271 @default.
• W2063093896 hasConceptScore W2063093896C181199279 @default.
• W2063093896 hasConceptScore W2063093896C185592680 @default.
• W2063093896 hasConceptScore W2063093896C204787440 @default.
• W2063093896 hasConceptScore W2063093896C27081682 @default.
• W2063093896 hasConceptScore W2063093896C2777180221 @default.
• W2063093896 hasConceptScore W2063093896C2777628954 @default.
• W2063093896 hasConceptScore W2063093896C2779689624 @default.
• W2063093896 hasConceptScore W2063093896C3018697912 @default.

• next