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• W2063129944 abstract "Cephalosporin C production process optimization was studied based on four experiments carried out in an agitated and aerated tank fermentor operated as a fed-batch reactor. The microorganism Cephalosporium acremonium ATCC 48272 (C-10) was cultivated in a synthetic medium containing glucose as major carbon and energy source. The additional medium contained a hydrolyzed sucrose solution as the main carbon and energy source and it was added after the glucose depletion. By manipulating the supplementary feed rate, it was possible to increase antibiotic production. A mathematical model to represent the fed-batch production process was developed. It was observed that the model was applicable under different operation conditions, showing that optimization studies can be made based on this model." @default.
• W2063129944 created "2016-06-24" @default.
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• W2063129944 date "1999-07-01" @default.
• W2063129944 modified "2023-10-01" @default.
• W2063129944 title "Modelling and optimization of the cephalosporin C production bioprocess in a fed-batch bioreactor with invert sugar as substrate" @default.
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• W2063129944 doi "https://doi.org/10.1016/s0009-2509(98)00364-9" @default.
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