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- W2063138558 abstract "Short courses of corticosteroids are commonly used to treat relapses of multiple sclerosis (MS). Intravenous methylprednisolone is generally used in a dose of 500-1000 mg per day for 3-5 days. Steroids affect a wide range of biological mechanisms, anti-inflammatory and immunomodulatory effects being especially pronounced. Although corticosteroids are superior to placebo in the treatment of relapses, and high-dose methylprednisolone may be superior to corticotropin, 1 Thompson AJ Kennard C Swash M et al. Relative efficacy of intravenous methylprednisolone and ACTH in the treatment of acute relapse in MS. Neurlogy. 1989; 39: 969-971 Crossref PubMed Google Scholar little is known about the best route of administration. Randomised trial of oral and intravenous methylprednisolone in acute relapses of multiple sclerosisSince our study did not show any clear advantage of the intravenous regime we conclude that it is preferable to prescribe oral rather than intravenous steroids for acute relapses in MS for reasons of patient convenience, safety, and cost. Full-Text PDF" @default.
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- W2063138558 title "Oral or intravenous methylprednisolone for acute relapses of MS?" @default.
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- W2063138558 doi "https://doi.org/10.1016/s0140-6736(05)62691-8" @default.
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