FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2063156687> ?p ?o ?g. }

• W2063156687 endingPage "553" @default.
• W2063156687 startingPage "543" @default.
• W2063156687 abstract "Large-conductance calcium-activated potassium channels (BK(Ca) channels) mediate physiological processes in nonexcitable cells.The aim of the study was to determine BK(Ca) channel expression in human endometrium and its role in endometrial receptivity and embryo implantation.BK(Ca) channel expression in human endometrium is described at different phases of the menstrual cycle using quantitative real time-PCR and Western blot techniques. Their effects on embryo implantation were examined using JAr spheroid attachment assays and in vivo mouse model. We examined their effects on endometrial receptivity factors, nuclear factor-κB (NF-κB) activity using quantitative real time-PCR, Western blot, and EMSA analyses. Changes in electrophysiological properties and cytosolic free Ca(2+) were measured in endometrial cells with or without specific BK(Ca) blocker or transfected with BK(Ca) small interfering RNA using patch-clamp and fluorescence analyses, respectively.BK(Ca) channels are expressed in human endometrial cells in a phase-related fashion during the menstrual cycle (proliferative, 0.20 ± 0.02, vs. mid-secretory, 0.72 ± 0.07; P < 0.01). Blocking BK(Ca) channel function or knockdown of endogenous BK(Ca) channel expression not only decreased JAr spheroid attachment rate and embryo implantation rate in mice but also significantly reduced the expression levels of endometrial receptive factors, including leukemia inhibitory factor, integrin β3, claudin-4, and DKK-1, in human endometrial cells. Blocking BK(Ca) channels also reduced BK(Ca)-regulated NF-κB activity, cytosolic Ca(2+) concentrations, and membrane potentials in human endometrial cells.These observations demonstrate that BK(Ca) channels: 1) are expressed in endometrial cells; 2) affect embryo implantation by mediating endometrial receptive factors; and 3) alter the activity of NF-κB and homeostasis of Ca(2+) in the human endometrial cells." @default.
• W2063156687 created "2016-06-24" @default.
• W2063156687 creator A5010483409 @default.
• W2063156687 creator A5015747340 @default.
• W2063156687 creator A5022765916 @default.
• W2063156687 creator A5026343875 @default.
• W2063156687 creator A5027564028 @default.
• W2063156687 creator A5032927018 @default.
• W2063156687 creator A5042448061 @default.
• W2063156687 creator A5067837521 @default.
• W2063156687 creator A5068419238 @default.
• W2063156687 creator A5081093007 @default.
• W2063156687 creator A5082978716 @default.
• W2063156687 creator A5086559201 @default.
• W2063156687 creator A5087134757 @default.
• W2063156687 date "2012-02-01" @default.
• W2063156687 modified "2023-09-26" @default.
• W2063156687 title "Functional Expression of Large-Conductance Calcium-Activated Potassium Channels in Human Endometrium: A Novel Mechanism Involved in Endometrial Receptivity and Embryo Implantation" @default.
• W2063156687 cites W1510470494 @default.
• W2063156687 cites W1598928144 @default.
• W2063156687 cites W1701691777 @default.
• W2063156687 cites W1832484307 @default.
• W2063156687 cites W1884656506 @default.
• W2063156687 cites W1971038847 @default.
• W2063156687 cites W1976154305 @default.
• W2063156687 cites W1977675449 @default.
• W2063156687 cites W1986791333 @default.
• W2063156687 cites W1987431351 @default.
• W2063156687 cites W1995559307 @default.
• W2063156687 cites W2001364107 @default.
• W2063156687 cites W2003778314 @default.
• W2063156687 cites W2007372862 @default.
• W2063156687 cites W2011091860 @default.
• W2063156687 cites W2023079616 @default.
• W2063156687 cites W2037547464 @default.
• W2063156687 cites W2039867038 @default.
• W2063156687 cites W2048665812 @default.
• W2063156687 cites W2049352189 @default.
• W2063156687 cites W2054565450 @default.
• W2063156687 cites W2054569293 @default.
• W2063156687 cites W2058922314 @default.
• W2063156687 cites W2068083065 @default.
• W2063156687 cites W2071899922 @default.
• W2063156687 cites W2085519984 @default.
• W2063156687 cites W2087280361 @default.
• W2063156687 cites W2102420543 @default.
• W2063156687 cites W2110906674 @default.
• W2063156687 cites W2114130914 @default.
• W2063156687 cites W2127983813 @default.
• W2063156687 cites W2136987198 @default.
• W2063156687 cites W2140384196 @default.
• W2063156687 cites W2141350283 @default.
• W2063156687 cites W2144641366 @default.
• W2063156687 cites W2155479958 @default.
• W2063156687 cites W2164566530 @default.
• W2063156687 cites W2171806725 @default.
• W2063156687 cites W2188714410 @default.
• W2063156687 doi "https://doi.org/10.1210/jc.2011-2108" @default.
• W2063156687 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22170720" @default.
• W2063156687 hasPublicationYear "2012" @default.
• W2063156687 type Work @default.
• W2063156687 sameAs 2063156687 @default.
• W2063156687 citedByCount "33" @default.
• W2063156687 countsByYear W20631566872012 @default.
• W2063156687 countsByYear W20631566872013 @default.
• W2063156687 countsByYear W20631566872014 @default.
• W2063156687 countsByYear W20631566872015 @default.
• W2063156687 countsByYear W20631566872016 @default.
• W2063156687 countsByYear W20631566872017 @default.
• W2063156687 countsByYear W20631566872018 @default.
• W2063156687 countsByYear W20631566872019 @default.
• W2063156687 countsByYear W20631566872020 @default.
• W2063156687 countsByYear W20631566872021 @default.
• W2063156687 countsByYear W20631566872022 @default.
• W2063156687 crossrefType "journal-article" @default.
• W2063156687 hasAuthorship W2063156687A5010483409 @default.
• W2063156687 hasAuthorship W2063156687A5015747340 @default.
• W2063156687 hasAuthorship W2063156687A5022765916 @default.
• W2063156687 hasAuthorship W2063156687A5026343875 @default.
• W2063156687 hasAuthorship W2063156687A5027564028 @default.
• W2063156687 hasAuthorship W2063156687A5032927018 @default.
• W2063156687 hasAuthorship W2063156687A5042448061 @default.
• W2063156687 hasAuthorship W2063156687A5067837521 @default.
• W2063156687 hasAuthorship W2063156687A5068419238 @default.
• W2063156687 hasAuthorship W2063156687A5081093007 @default.
• W2063156687 hasAuthorship W2063156687A5082978716 @default.
• W2063156687 hasAuthorship W2063156687A5086559201 @default.
• W2063156687 hasAuthorship W2063156687A5087134757 @default.
• W2063156687 hasBestOaLocation W20631566871 @default.
• W2063156687 hasConcept C126322002 @default.
• W2063156687 hasConcept C134018914 @default.
• W2063156687 hasConcept C185592680 @default.
• W2063156687 hasConcept C196843134 @default.
• W2063156687 hasConcept C22615655 @default.
• W2063156687 hasConcept C2779742232 @default.
• W2063156687 hasConcept C54009773 @default.
• W2063156687 hasConcept C54355233 @default.
• W2063156687 hasConcept C61144316 @default.

• next