Matches in SemOpenAlex for { <https://semopenalex.org/work/W2063162012> ?p ?o ?g. }
- W2063162012 endingPage "394" @default.
- W2063162012 startingPage "387" @default.
- W2063162012 abstract "Selenium is an essential element incorporated into selenoproteins. Selenium deficiency may predispose to immune deficiency, mood disorders, and cancer. On the other hand, excessive environmental exposure to selenite may cause a variety of disorders including anemia. At least in theory, the anemia could result from accelerated suicidal erythrocyte death or eryptosis, characterized by cell shrinkage and phosphatidylserine exposure at the erythrocyte surface. Eryptosis is triggered by an increase in the cytosolic Ca(2+) concentration and by ceramide. The present experiments explored, whether high concentrations of selenite stimulate eryptosis. According to Fluo3 fluorescence, selenite (>or=200 microg/l sodium selenite) within 48 hours significantly increased the cytosolic Ca(2+) concentration in human erythrocytes. According to binding of selective fluorescent antibodies, selenite (>or= 200 microg/l) significantly increased ceramide formation. Annexin V-binding demonstrated that selenite (>or=200 microg/l) significantly increased phosphatidylserine exposure of erythrocytes. Forward scatter analysis further revealed that selenite (>or=200 microg/l) significantly decreased cell volume. In contrast to selenite, selenate failed to trigger eryptosis. In conclusion, selenite triggers suicidal erythrocyte death at least partially by increasing the cytosolic Ca(2+) concentration and by stimulating the formation of ceramide. The present study discloses novel cellular effects of this essential nutrient." @default.
- W2063162012 created "2016-06-24" @default.
- W2063162012 creator A5025098806 @default.
- W2063162012 creator A5041073789 @default.
- W2063162012 creator A5061162593 @default.
- W2063162012 creator A5084208566 @default.
- W2063162012 date "2008-01-01" @default.
- W2063162012 modified "2023-10-16" @default.
- W2063162012 title "Suicidal Death of Erythrocytes Due to Selenium-Compounds" @default.
- W2063162012 cites W1500574894 @default.
- W2063162012 cites W1550748681 @default.
- W2063162012 cites W1612835954 @default.
- W2063162012 cites W1837480492 @default.
- W2063162012 cites W1908806163 @default.
- W2063162012 cites W1963571039 @default.
- W2063162012 cites W1965432497 @default.
- W2063162012 cites W1966598894 @default.
- W2063162012 cites W1966685713 @default.
- W2063162012 cites W1969776684 @default.
- W2063162012 cites W1971560937 @default.
- W2063162012 cites W1975003156 @default.
- W2063162012 cites W1976466808 @default.
- W2063162012 cites W1978504114 @default.
- W2063162012 cites W1979629446 @default.
- W2063162012 cites W1979697480 @default.
- W2063162012 cites W1983418648 @default.
- W2063162012 cites W1985040456 @default.
- W2063162012 cites W1996497038 @default.
- W2063162012 cites W1997519809 @default.
- W2063162012 cites W2002308686 @default.
- W2063162012 cites W2003505368 @default.
- W2063162012 cites W2003675056 @default.
- W2063162012 cites W2003764830 @default.
- W2063162012 cites W2004510097 @default.
- W2063162012 cites W2005252355 @default.
- W2063162012 cites W2010189469 @default.
- W2063162012 cites W2011433123 @default.
- W2063162012 cites W2014189646 @default.
- W2063162012 cites W2014441588 @default.
- W2063162012 cites W2016299124 @default.
- W2063162012 cites W2019471670 @default.
- W2063162012 cites W2025234694 @default.
- W2063162012 cites W2028981778 @default.
- W2063162012 cites W2031230249 @default.
- W2063162012 cites W2033978865 @default.
- W2063162012 cites W2036961219 @default.
- W2063162012 cites W2038819783 @default.
- W2063162012 cites W2039616271 @default.
- W2063162012 cites W2039659095 @default.
- W2063162012 cites W2039799350 @default.
- W2063162012 cites W2043119510 @default.
- W2063162012 cites W2045233156 @default.
- W2063162012 cites W2047768756 @default.
- W2063162012 cites W2049569719 @default.
- W2063162012 cites W2050571341 @default.
- W2063162012 cites W2051520080 @default.
- W2063162012 cites W2052059282 @default.
- W2063162012 cites W2052726190 @default.
- W2063162012 cites W2061902383 @default.
- W2063162012 cites W2061908395 @default.
- W2063162012 cites W2062185639 @default.
- W2063162012 cites W2065641335 @default.
- W2063162012 cites W2066878245 @default.
- W2063162012 cites W2072170658 @default.
- W2063162012 cites W2074702983 @default.
- W2063162012 cites W2074728848 @default.
- W2063162012 cites W2076896298 @default.
- W2063162012 cites W2078137514 @default.
- W2063162012 cites W2086510768 @default.
- W2063162012 cites W2088533769 @default.
- W2063162012 cites W2089976554 @default.
- W2063162012 cites W2092025193 @default.
- W2063162012 cites W2098000156 @default.
- W2063162012 cites W2100641244 @default.
- W2063162012 cites W2101632221 @default.
- W2063162012 cites W2102807564 @default.
- W2063162012 cites W2106001223 @default.
- W2063162012 cites W2106804145 @default.
- W2063162012 cites W2111937773 @default.
- W2063162012 cites W2113053099 @default.
- W2063162012 cites W2118611619 @default.
- W2063162012 cites W2119906602 @default.
- W2063162012 cites W2121958153 @default.
- W2063162012 cites W2127125651 @default.
- W2063162012 cites W2130693604 @default.
- W2063162012 cites W2131523916 @default.
- W2063162012 cites W2132153731 @default.
- W2063162012 cites W2137056920 @default.
- W2063162012 cites W2148045277 @default.
- W2063162012 cites W2148394321 @default.
- W2063162012 cites W2152736786 @default.
- W2063162012 cites W2156923138 @default.
- W2063162012 cites W2159797128 @default.
- W2063162012 cites W2161075922 @default.
- W2063162012 cites W2163233470 @default.
- W2063162012 cites W2172224722 @default.
- W2063162012 cites W2226534825 @default.
- W2063162012 cites W2316945586 @default.