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- W2063162158 abstract "Ciliary neurotrophic factor and bone morphogenetic proteins induce astrocytogenesis in the developing rat brain by stimulating STAT- and Smad-dependent signaling, respectively. We previously found that stimulation of the cAMP-dependent signaling pathway also triggers differentiation of cerebral cortical precursor cells into astrocytes, providing an additional mechanism to promote astrocyte differentiation. In this study, we show that pituitary adenylate cyclase-activating polypeptide (PACAP), but not the related vasoactive intestinal peptide, induces astrocyte differentiation of cortical precursor cells, even after a transient exposure. Cortical precursors were found to express predominantly the short isoform of the PACAP-specific PAC1 receptor, which couples to adenylate cyclase. Consistent with this notion, we determined that exposure of cortical precursors to PACAP resulted in a dose-dependent increase in cAMP production. Pretreatment of cells with the cAMP antagonist Rp-cAMPS prevented astrocyte differentiation. Thus, PACAP acts as an extracellular signal to trigger cortical precursor cell differentiation into astrocytes via stimulation of intracellular cAMP production." @default.
- W2063162158 created "2016-06-24" @default.
- W2063162158 creator A5054477284 @default.
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- W2063162158 date "2002-12-01" @default.
- W2063162158 modified "2023-10-13" @default.
- W2063162158 title "Pituitary Adenylate Cyclase-Activating Polypeptide Induces Astrocyte Differentiation of Precursor Cells from Developing Cerebral Cortex" @default.
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- W2063162158 doi "https://doi.org/10.1006/mcne.2002.1189" @default.
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