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- W2063166500 abstract "Tumours of the spinal cord are associated with high morbidity but, owing to the rarity of such tumours, our understanding of the biology of these lesions is limited. In this Review, Zadnik et al. summarize current knowledge on the demographics, genetics and treatment of the most common spinal cord tumours—namely, ependymomas, astrocytomas, haemangioblastomas and meningiomas—and highlight how recent advances in genetic studies are informing research to develop novel therapeutic approaches. Tumours of the spinal cord, although rare, are associated with high morbidity. Surgical resection remains the primary treatment for patients with this disease, and offers the best chance for cure. Such surgical procedures, however, carry substantial risks such as worsening of neurological deficit, paralysis and death. New therapeutic avenues for spinal cord tumours are needed, but genetic studies of the molecular mechanisms governing tumourigenesis in the spinal cord are limited by the scarcity of high-quality human tumour samples. Many spinal cord tumours have intracranial counterparts that have been extensively studied, but emerging data show that the tumours are genetically and biologically distinct. The differences between brain and spine tumours make extrapolation of data from one to the other difficult. In this Review, we describe the demographics, genetics and current treatment approaches for the most commonly encountered spinal cord tumours—namely, ependymomas, astrocytomas, haemangioblastomas and meningiomas. We highlight advances in understanding of the biological basis of these lesions, and explain how the latest progress in genetics and beyond are being translated to improve patient care." @default.
- W2063166500 created "2016-06-24" @default.
- W2063166500 creator A5026609192 @default.
- W2063166500 creator A5050797624 @default.
- W2063166500 creator A5069558252 @default.
- W2063166500 creator A5069696402 @default.
- W2063166500 date "2013-03-26" @default.
- W2063166500 modified "2023-10-13" @default.
- W2063166500 title "Spinal cord tumours: advances in genetics and their implications for treatment" @default.
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