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• W2063171346 endingPage "R1797" @default.
• W2063171346 startingPage "R1787" @default.
• W2063171346 abstract "Epithelial sodium channels (ENaC) are important for regulating sodium transport across epithelia. Functional studies indicate that neural mechanisms acting through mineralocorticoid receptors (MR) and sodium channels (presumably ENaC) are crucial to the development of sympathoexcitation and hypertension in experimental models of salt-sensitive hypertension. However, expression and localization of the ENaC in cardiovascular regulatory centers of the brain have not yet been studied. RT-PCR and immunohistochemistry were performed to study ENaC and MR expression at the mRNA and protein levels, respectively. Both mRNA and protein for α-, β-, and γ-ENaC subunits and MR were found to be expressed in the rat brain. All three ENaC subunits and MR were present in the supraoptic nucleus, magnocellular paraventricular nucleus, hippocampus, choroid plexus, ependyma, and brain blood vessels, suggesting the presence of multimeric channels and possible regulation by mineralocorticoids. In most cortical areas, thalamus, amygdala, and suprachiasmatic nucleus, notable expression of γ-ENaC was undetectable, whereas α- and β-ENaC were abundantly expressed pointing to the possibility of a heterogeneous population of channels. The findings suggest that stoichiometrically different populations of ENaC may be present in both epithelial and neural components in the brain, which may contribute to regulation of cerebrospinal fluid and interstitial Na + concentration as well as neuronal excitation." @default.
• W2063171346 created "2016-06-24" @default.
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• W2063171346 date "2005-12-01" @default.
• W2063171346 modified "2023-10-16" @default.
• W2063171346 title "Distribution of epithelial sodium channels and mineralocorticoid receptors in cardiovascular regulatory centers in rat brain" @default.
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• W2063171346 doi "https://doi.org/10.1152/ajpregu.00063.2005" @default.
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• W2063171346 hasPublicationYear "2005" @default.
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