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• W2063193324 abstract "The synthesis and biological evaluation of a number of differently substituted 3,6-diamino-1H-pyrazolo[3,4-b]pyridine derivatives are reported. From the inhibition results on a selection of disease-relevant protein kinases [IC(50) (microM) DYRK1A=11; CDK5=0.41; GSK-3=1.5] we have observed that 3,6-diamino-4-phenyl-1H-pyrazolo[3,4-b]pyridine-5-carbonitrile (4) constitutes a potential new and simple lead compound in the search of drugs for the treatment of Alzheimer's disease." @default.
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• W2063193324 date "2009-08-01" @default.
• W2063193324 modified "2023-10-05" @default.
• W2063193324 title "Synthesis and biological evaluation of 3,6-diamino-1H-pyrazolo[3,4-b]pyridine derivatives as protein kinase inhibitors" @default.
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• W2063193324 doi "https://doi.org/10.1016/j.bmcl.2009.06.099" @default.
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