Matches in SemOpenAlex for { <https://semopenalex.org/work/W2063222333> ?p ?o ?g. }
- W2063222333 endingPage "12" @default.
- W2063222333 startingPage "1" @default.
- W2063222333 abstract "Felodipine, a poorly soluble drug, is widely used in the treatment of angina pectoris and hypertension.This study aimed at the preparation of amorphous solid dispersion (SD) of felodipine using an amphiphilic polymer, soluplus, for the potential enhancement in solubility of the drug.Solid dispersions with varying proportions of drug and soluplus were prepared and the rate and extent of dissolution from SDs was compared with that of the pure drug. FT-IR and (1)H NMR spectroscopic analysis were carried out to examine the formation mechanism of SDs. Various techniques were used for solid state characterization of designed SDs.Formation of amorphous solid dispersions with particle size in nanometer range indicated suitability of polymer and method used in the preparation. FT-IR and (1)H NMR spectroscopy revealed that soluplus was involved in strong hydrogen bonding with felodipine molecules which resulted in the conversion of crystalline felodipine into amorphous form. Solid dispersion with 1:10 drug/polymer ratio showed more than 90% drug dissolution in 30 min whereas pure felodipine showed less than 19% drug dissolution in 1 h.Amorphous SDs of felodipine were prepared using soluplus resulting in substantial enhancement in the rate and extent of dissolution of felodipine." @default.
- W2063222333 created "2016-06-24" @default.
- W2063222333 creator A5016528277 @default.
- W2063222333 creator A5027002109 @default.
- W2063222333 creator A5055699086 @default.
- W2063222333 creator A5063556803 @default.
- W2063222333 creator A5076453357 @default.
- W2063222333 date "2015-03-17" @default.
- W2063222333 modified "2023-09-26" @default.
- W2063222333 title "Dissolution enhancement of felodipine by amorphous nanodispersions using an amphiphilic polymer: insight into the role of drug–polymer interactions on drug dissolution" @default.
- W2063222333 cites W102724740 @default.
- W2063222333 cites W1966385056 @default.
- W2063222333 cites W1972559099 @default.
- W2063222333 cites W1975230163 @default.
- W2063222333 cites W1977065263 @default.
- W2063222333 cites W1984335257 @default.
- W2063222333 cites W1986475553 @default.
- W2063222333 cites W1998970318 @default.
- W2063222333 cites W1999211462 @default.
- W2063222333 cites W2001596955 @default.
- W2063222333 cites W2006657575 @default.
- W2063222333 cites W2009938495 @default.
- W2063222333 cites W2014774096 @default.
- W2063222333 cites W2023049080 @default.
- W2063222333 cites W2025463706 @default.
- W2063222333 cites W2038295804 @default.
- W2063222333 cites W2043865641 @default.
- W2063222333 cites W2044594845 @default.
- W2063222333 cites W2057617927 @default.
- W2063222333 cites W2058261527 @default.
- W2063222333 cites W205849754 @default.
- W2063222333 cites W2069506489 @default.
- W2063222333 cites W2071055965 @default.
- W2063222333 cites W2071060910 @default.
- W2063222333 cites W2077594374 @default.
- W2063222333 cites W2078814811 @default.
- W2063222333 cites W2081082515 @default.
- W2063222333 cites W2081833333 @default.
- W2063222333 cites W2084240605 @default.
- W2063222333 cites W2085535677 @default.
- W2063222333 cites W2094506063 @default.
- W2063222333 cites W2126397755 @default.
- W2063222333 cites W2143882454 @default.
- W2063222333 cites W2149111315 @default.
- W2063222333 cites W2151114776 @default.
- W2063222333 cites W2315253121 @default.
- W2063222333 cites W2611501754 @default.
- W2063222333 cites W2611527592 @default.
- W2063222333 cites W80550314 @default.
- W2063222333 doi "https://doi.org/10.3109/10837450.2015.1022785" @default.
- W2063222333 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25777532" @default.
- W2063222333 hasPublicationYear "2015" @default.
- W2063222333 type Work @default.
- W2063222333 sameAs 2063222333 @default.
- W2063222333 citedByCount "6" @default.
- W2063222333 countsByYear W20632223332015 @default.
- W2063222333 countsByYear W20632223332017 @default.
- W2063222333 countsByYear W20632223332020 @default.
- W2063222333 countsByYear W20632223332021 @default.
- W2063222333 crossrefType "journal-article" @default.
- W2063222333 hasAuthorship W2063222333A5016528277 @default.
- W2063222333 hasAuthorship W2063222333A5027002109 @default.
- W2063222333 hasAuthorship W2063222333A5055699086 @default.
- W2063222333 hasAuthorship W2063222333A5063556803 @default.
- W2063222333 hasAuthorship W2063222333A5076453357 @default.
- W2063222333 hasConcept C120665830 @default.
- W2063222333 hasConcept C121332964 @default.
- W2063222333 hasConcept C126838900 @default.
- W2063222333 hasConcept C127413603 @default.
- W2063222333 hasConcept C14029885 @default.
- W2063222333 hasConcept C155574463 @default.
- W2063222333 hasConcept C177562468 @default.
- W2063222333 hasConcept C178790620 @default.
- W2063222333 hasConcept C185592680 @default.
- W2063222333 hasConcept C192562407 @default.
- W2063222333 hasConcept C2780648877 @default.
- W2063222333 hasConcept C2781430271 @default.
- W2063222333 hasConcept C42360764 @default.
- W2063222333 hasConcept C521977710 @default.
- W2063222333 hasConcept C56052488 @default.
- W2063222333 hasConcept C71924100 @default.
- W2063222333 hasConcept C84393581 @default.
- W2063222333 hasConcept C88380143 @default.
- W2063222333 hasConceptScore W2063222333C120665830 @default.
- W2063222333 hasConceptScore W2063222333C121332964 @default.
- W2063222333 hasConceptScore W2063222333C126838900 @default.
- W2063222333 hasConceptScore W2063222333C127413603 @default.
- W2063222333 hasConceptScore W2063222333C14029885 @default.
- W2063222333 hasConceptScore W2063222333C155574463 @default.
- W2063222333 hasConceptScore W2063222333C177562468 @default.
- W2063222333 hasConceptScore W2063222333C178790620 @default.
- W2063222333 hasConceptScore W2063222333C185592680 @default.
- W2063222333 hasConceptScore W2063222333C192562407 @default.
- W2063222333 hasConceptScore W2063222333C2780648877 @default.
- W2063222333 hasConceptScore W2063222333C2781430271 @default.
- W2063222333 hasConceptScore W2063222333C42360764 @default.
- W2063222333 hasConceptScore W2063222333C521977710 @default.
- W2063222333 hasConceptScore W2063222333C56052488 @default.