Matches in SemOpenAlex for { <https://semopenalex.org/work/W2063229165> ?p ?o ?g. }
- W2063229165 endingPage "1516" @default.
- W2063229165 startingPage "1511" @default.
- W2063229165 abstract "The lactate dehydrogenase A ( LDH-A ) gene, whose product participates in normal anaerobic glycolysis and is frequently increased in human cancers, has been identified as a c-Myc-responsive gene. It was of interest, therefore, to compare the effect of glucose deprivation in c-Myc-transformed and nontransformed cells. We observed that glucose deprivation or treatment with the glucose antimetabolite 2-deoxyglucose caused nontransformed cells to arrest in the G 0 /G 1 phase of the cell cycle. In contrast, c-Myc-transformed fibroblasts, lymphoblastoid, or lung carcinoma cells underwent extensive apoptosis. Ectopic expression of LDH-A alone in Rat1a fibroblasts was sufficient to induce apoptosis with glucose deprivation but not with serum withdrawal, suggesting that LDH-A mediates the unique apoptotic effect of c-Myc when glycolysis is blocked. The apoptosis caused by glucose deprivation was blocked by Bcl-2 expression but appeared to be independent of wild-type p53 activity. These studies provide insights on the coupling of glucose metabolism and the cell cycle in c-Myc-transformed cells and may in the future be exploited for cancer therapeutics." @default.
- W2063229165 created "2016-06-24" @default.
- W2063229165 creator A5004300660 @default.
- W2063229165 creator A5035387431 @default.
- W2063229165 creator A5053850518 @default.
- W2063229165 creator A5059108231 @default.
- W2063229165 date "1998-02-17" @default.
- W2063229165 modified "2023-10-16" @default.
- W2063229165 title "A unique glucose-dependent apoptotic pathway induced by c-Myc" @default.
- W2063229165 cites W128302075 @default.
- W2063229165 cites W1503667331 @default.
- W2063229165 cites W1506002717 @default.
- W2063229165 cites W1521424334 @default.
- W2063229165 cites W1537539007 @default.
- W2063229165 cites W1541680266 @default.
- W2063229165 cites W1548610182 @default.
- W2063229165 cites W1590434810 @default.
- W2063229165 cites W1642592182 @default.
- W2063229165 cites W1762412578 @default.
- W2063229165 cites W1804584144 @default.
- W2063229165 cites W1969486602 @default.
- W2063229165 cites W1971645561 @default.
- W2063229165 cites W1995397953 @default.
- W2063229165 cites W1997208169 @default.
- W2063229165 cites W1999334756 @default.
- W2063229165 cites W2010394923 @default.
- W2063229165 cites W2011348663 @default.
- W2063229165 cites W2013330927 @default.
- W2063229165 cites W2021285193 @default.
- W2063229165 cites W2029113656 @default.
- W2063229165 cites W2032972450 @default.
- W2063229165 cites W2043395027 @default.
- W2063229165 cites W2058218780 @default.
- W2063229165 cites W2064670731 @default.
- W2063229165 cites W2068889468 @default.
- W2063229165 cites W2068909560 @default.
- W2063229165 cites W2072046909 @default.
- W2063229165 cites W2081948388 @default.
- W2063229165 cites W2093080620 @default.
- W2063229165 cites W2097447643 @default.
- W2063229165 cites W2100057506 @default.
- W2063229165 cites W2106410559 @default.
- W2063229165 cites W2130227763 @default.
- W2063229165 cites W2154214377 @default.
- W2063229165 cites W2162468227 @default.
- W2063229165 cites W2172103753 @default.
- W2063229165 cites W2409153565 @default.
- W2063229165 cites W2419644505 @default.
- W2063229165 cites W604269278 @default.
- W2063229165 cites W7405620 @default.
- W2063229165 cites W1978336860 @default.
- W2063229165 doi "https://doi.org/10.1073/pnas.95.4.1511" @default.
- W2063229165 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/19067" @default.
- W2063229165 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9465046" @default.
- W2063229165 hasPublicationYear "1998" @default.
- W2063229165 type Work @default.
- W2063229165 sameAs 2063229165 @default.
- W2063229165 citedByCount "264" @default.
- W2063229165 countsByYear W20632291652012 @default.
- W2063229165 countsByYear W20632291652013 @default.
- W2063229165 countsByYear W20632291652014 @default.
- W2063229165 countsByYear W20632291652015 @default.
- W2063229165 countsByYear W20632291652016 @default.
- W2063229165 countsByYear W20632291652017 @default.
- W2063229165 countsByYear W20632291652018 @default.
- W2063229165 countsByYear W20632291652019 @default.
- W2063229165 countsByYear W20632291652020 @default.
- W2063229165 countsByYear W20632291652021 @default.
- W2063229165 countsByYear W20632291652022 @default.
- W2063229165 countsByYear W20632291652023 @default.
- W2063229165 crossrefType "journal-article" @default.
- W2063229165 hasAuthorship W2063229165A5004300660 @default.
- W2063229165 hasAuthorship W2063229165A5035387431 @default.
- W2063229165 hasAuthorship W2063229165A5053850518 @default.
- W2063229165 hasAuthorship W2063229165A5059108231 @default.
- W2063229165 hasBestOaLocation W20632291652 @default.
- W2063229165 hasConcept C104317684 @default.
- W2063229165 hasConcept C109156525 @default.
- W2063229165 hasConcept C134018914 @default.
- W2063229165 hasConcept C17093226 @default.
- W2063229165 hasConcept C181199279 @default.
- W2063229165 hasConcept C190283241 @default.
- W2063229165 hasConcept C20251656 @default.
- W2063229165 hasConcept C2777318727 @default.
- W2063229165 hasConcept C2777866211 @default.
- W2063229165 hasConcept C2779306644 @default.
- W2063229165 hasConcept C2910680157 @default.
- W2063229165 hasConcept C29537977 @default.
- W2063229165 hasConcept C502942594 @default.
- W2063229165 hasConcept C54355233 @default.
- W2063229165 hasConcept C55493867 @default.
- W2063229165 hasConcept C55885012 @default.
- W2063229165 hasConcept C62231903 @default.
- W2063229165 hasConcept C81885089 @default.
- W2063229165 hasConcept C86803240 @default.
- W2063229165 hasConcept C95444343 @default.
- W2063229165 hasConcept C97037327 @default.
- W2063229165 hasConceptScore W2063229165C104317684 @default.