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- W2063231899 abstract "Genetic determinants of the autoimmune type of chronic active hepatitis include the major histocompatibility complex alleles HLA-B8 and HLA-DR3, which are usually present as the haplotype A1, B8, DR3. In certain other autoimmune diseases, an extended haplotype including complement alleles confers a greater relative risk than does B8, DR3. Hence, extended haplotypes were ascertained in autoimmune chronic active hepatitis by typing for HLA, complement alleles C4A, C4B, and Bf, and glyoxalase type 1 or 2. Eight of the 10 B8, DR3 haplotypes were A1, B8, DR3. Of the 8, 7 had the extended haplotype A1, B8, C4AQ0, C4B1, BfS, DR3, but this haplotype occurred in four instances with glyoxalase 2 and in three with glyoxalase 1. Thus, we find that in autoimmune chronic active hepatitis there is a high frequency of null alleles for complement but an extended haplotype does not cause any greater risk for disease than B8, DR3 alone." @default.
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- W2063231899 date "2013-12-01" @default.
- W2063231899 modified "2023-09-26" @default.
- W2063231899 title "Low C4 gene copy numbers are associated with superior graft survival in patients transplanted with a deceased donor kidney" @default.
- W2063231899 doi "https://doi.org/10.1016/j.molimm.2013.05.101" @default.
- W2063231899 hasPublicationYear "2013" @default.
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