FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2063232675> ?p ?o ?g. }

• W2063232675 abstract "The mechanisms underlying the relative insensitivity of the renal medullary circulation to renal sympathetic nerve stimulation (RNS) remain unknown. Therefore, we tested the effects of systemic alpha(1)- and alpha(2)-adrenoceptor blockade on responses to electrical RNS in pentobarbitone anaesthetized rabbits. Renal blood flow (RBF), cortical laser Doppler flux (CLDF), and to a lesser extent medullary LDF (MLDF) were reduced by RNS in a frequency-dependent manner. Prazosin decreased responses of RBF and CLDF, but not MLDF, to RNS. For example, during the control period 4 Hz stimulation reduced RBF, CLDF and MLDF by 85+/-3%, 89+/-2%, and 20+/-12%, respectively, but after prazosin, corresponding responses were 39+/-3%, 42+/-5% and 28+/-7%, respectively. Prazosin markedly blunted pressor and renal vasoconstrictor responses to intravenous phenylephrine, without altering pressor responses to intravenous xylazine. Rauwolscine enhanced renal vasoconstrictor responses to RNS, although this was statistically significant for RBF and CLDF but not MLDF. For example, during the control period 2 Hz stimulation reduced RBF, CLDF and MLDF by 63+/-7%, 58+/-7%, and 29+/-17%, respectively, and after rauwolscine, corresponding responses were 83+/-4%, 87+/-1%, and 53+/-12%, respectively. Rauwolscine markedly blunted renal vasoconstrictor responses to renal arterial guanabenz, but not phenylephrine. These data suggest that alpha(1)-adrenoceptors contribute to RNS-induced vasoconstriction in the renal cortex, but contribute less in vascular elements controlling medullary perfusion. Activation of alpha(2)-adrenoceptors appears to blunt RNS-induced renal vasoconstriction, but this mechanism does not underlie the relative insensitivity of medullary perfusion to RNS." @default.
• W2063232675 created "2016-06-24" @default.
• W2063232675 creator A5008046838 @default.
• W2063232675 creator A5012270101 @default.
• W2063232675 creator A5063795274 @default.
• W2063232675 date "2004-05-01" @default.
• W2063232675 modified "2023-09-25" @default.
• W2063232675 title "α-Adrenoceptor subtypes mediating regional kidney blood flow responses to renal nerve stimulation" @default.
• W2063232675 cites W1562542129 @default.
• W2063232675 cites W1853270178 @default.
• W2063232675 cites W1930499844 @default.
• W2063232675 cites W1939758066 @default.
• W2063232675 cites W1967232940 @default.
• W2063232675 cites W1972826417 @default.
• W2063232675 cites W1977072705 @default.
• W2063232675 cites W1984362583 @default.
• W2063232675 cites W1989854140 @default.
• W2063232675 cites W2008136377 @default.
• W2063232675 cites W2014241997 @default.
• W2063232675 cites W2015834063 @default.
• W2063232675 cites W2018094653 @default.
• W2063232675 cites W2018452659 @default.
• W2063232675 cites W2025944726 @default.
• W2063232675 cites W2037259845 @default.
• W2063232675 cites W2043192122 @default.
• W2063232675 cites W2052903768 @default.
• W2063232675 cites W2073683436 @default.
• W2063232675 cites W2073710276 @default.
• W2063232675 cites W2075355594 @default.
• W2063232675 cites W2082909259 @default.
• W2063232675 cites W2088913694 @default.
• W2063232675 cites W2090198231 @default.
• W2063232675 cites W2119592801 @default.
• W2063232675 cites W2123841491 @default.
• W2063232675 cites W2124853370 @default.
• W2063232675 cites W2144826037 @default.
• W2063232675 cites W2145027155 @default.
• W2063232675 cites W2160908637 @default.
• W2063232675 cites W2185943746 @default.
• W2063232675 cites W2188510840 @default.
• W2063232675 cites W2202209993 @default.
• W2063232675 cites W2231317479 @default.
• W2063232675 cites W2281229447 @default.
• W2063232675 cites W2324263656 @default.
• W2063232675 cites W2402249145 @default.
• W2063232675 cites W2418304740 @default.
• W2063232675 cites W2418518771 @default.
• W2063232675 cites W2798643531 @default.
• W2063232675 cites W3213095525 @default.
• W2063232675 doi "https://doi.org/10.1016/j.autneu.2004.03.001" @default.
• W2063232675 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15233926" @default.
• W2063232675 hasPublicationYear "2004" @default.
• W2063232675 type Work @default.
• W2063232675 sameAs 2063232675 @default.
• W2063232675 citedByCount "17" @default.
• W2063232675 countsByYear W20632326752012 @default.
• W2063232675 countsByYear W20632326752013 @default.
• W2063232675 countsByYear W20632326752016 @default.
• W2063232675 crossrefType "journal-article" @default.
• W2063232675 hasAuthorship W2063232675A5008046838 @default.
• W2063232675 hasAuthorship W2063232675A5012270101 @default.
• W2063232675 hasAuthorship W2063232675A5063795274 @default.
• W2063232675 hasConcept C126322002 @default.
• W2063232675 hasConcept C134018914 @default.
• W2063232675 hasConcept C142225936 @default.
• W2063232675 hasConcept C170493617 @default.
• W2063232675 hasConcept C24998067 @default.
• W2063232675 hasConcept C2776504411 @default.
• W2063232675 hasConcept C2776885963 @default.
• W2063232675 hasConcept C2777952589 @default.
• W2063232675 hasConcept C2779961880 @default.
• W2063232675 hasConcept C2780091579 @default.
• W2063232675 hasConcept C2780648677 @default.
• W2063232675 hasConcept C2781073237 @default.
• W2063232675 hasConcept C71924100 @default.
• W2063232675 hasConcept C84393581 @default.
• W2063232675 hasConceptScore W2063232675C126322002 @default.
• W2063232675 hasConceptScore W2063232675C134018914 @default.
• W2063232675 hasConceptScore W2063232675C142225936 @default.
• W2063232675 hasConceptScore W2063232675C170493617 @default.
• W2063232675 hasConceptScore W2063232675C24998067 @default.
• W2063232675 hasConceptScore W2063232675C2776504411 @default.
• W2063232675 hasConceptScore W2063232675C2776885963 @default.
• W2063232675 hasConceptScore W2063232675C2777952589 @default.
• W2063232675 hasConceptScore W2063232675C2779961880 @default.
• W2063232675 hasConceptScore W2063232675C2780091579 @default.
• W2063232675 hasConceptScore W2063232675C2780648677 @default.
• W2063232675 hasConceptScore W2063232675C2781073237 @default.
• W2063232675 hasConceptScore W2063232675C71924100 @default.
• W2063232675 hasConceptScore W2063232675C84393581 @default.
• W2063232675 hasLocation W20632326751 @default.
• W2063232675 hasLocation W20632326752 @default.
• W2063232675 hasOpenAccess W2063232675 @default.
• W2063232675 hasPrimaryLocation W20632326751 @default.
• W2063232675 hasRelatedWork W1516488766 @default.
• W2063232675 hasRelatedWork W1966357256 @default.
• W2063232675 hasRelatedWork W1970854543 @default.
• W2063232675 hasRelatedWork W1983321239 @default.
• W2063232675 hasRelatedWork W2060498932 @default.
• W2063232675 hasRelatedWork W2063232675 @default.

• next