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- W2063240078 abstract "The viral enzyme integrase is essential for the replication of HIV-1 and, after the discovery of Isentress™, represents a validated target for anti-retroviral therapy. Incorporation of the dihydroxycarbonyl pharmacophore into a pyrrolinone scaffold led to the discovery of 5-pyrrolinone-3-carboxamides as a structurally diverse class of HIV-1 integrase inhibitors." @default.
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- W2063240078 date "2008-07-01" @default.
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- W2063240078 title "4-Hydroxy-5-pyrrolinone-3-carboxamide HIV-1 integrase inhibitors" @default.
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- W2063240078 doi "https://doi.org/10.1016/j.bmcl.2008.06.056" @default.
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