FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2063278306> ?p ?o ?g. }

• W2063278306 endingPage "326" @default.
• W2063278306 startingPage "315" @default.
• W2063278306 abstract "Dopamine agonists with a high affinity for D2 and D3 receptors have a biphasic effect on rodent locomotion, inducing hypolocomotion at low doses and hyperlocomotion at higher doses. Controversy surrounds the role of the D3 receptor in mediating the hypolocomotor response to low agonist doses. This study examines patterns of neuronal activation induced by varying doses of the D2/D3 receptor agonist quinelorane using blood oxygen level dependent (BOLD) pharmacological magnetic resonance imaging (phMRI), and compares them with corresponding behavioural responses. Quinelorane (3 microg/kg) induced hypolocomotion in rats naive to the testing environment, and in phMRI experiments increased neuronal activity within the anterior olfactory nuclei, nucleus accumbens and islets of Calleja, regions containing a high density of D3 receptors. A 30 microg/kg dose of quinelorane resulted in biphasic locomotor effects, with initial hypolocomotion followed by sustained hyperlocomotion. phMRI indicated that this higher dose increased cerebral activity within limbic and olfactory regions, as did the lower drug dose, but induced additional activation in the caudate-putamen and globus pallidus, areas dense in D2 receptors but containing few D3 receptors. The more restricted pattern of activation at low agonist doses and close temporal relationship between behavioural and BOLD signal responses to quinelorane suggest that those nuclei most dense in D3 receptors play a key role in mediating the hypolocomotor effects of quinelorane. However, the presence of D3 receptors in activated brain regions may be coincidental, and further studies are required to show definitively which class of receptors mediates agonist-induced hypolocomotion. In contrast, the activation of D2 receptors within the striatum appears necessary for quinelorane-induced hyperlocomotion." @default.
• W2063278306 created "2016-06-24" @default.
• W2063278306 creator A5007933977 @default.
• W2063278306 creator A5026314193 @default.
• W2063278306 creator A5030810824 @default.
• W2063278306 creator A5041146029 @default.
• W2063278306 creator A5045174960 @default.
• W2063278306 creator A5067611395 @default.
• W2063278306 date "2005-01-01" @default.
• W2063278306 modified "2023-10-14" @default.
• W2063278306 title "Mapping the effects of the selective dopamine D2/D3 receptor agonist quinelorane using pharmacological magnetic resonance imaging" @default.
• W2063278306 cites W1509194348 @default.
• W2063278306 cites W1530282405 @default.
• W2063278306 cites W1965680724 @default.
• W2063278306 cites W1966092598 @default.
• W2063278306 cites W1967009686 @default.
• W2063278306 cites W1969748095 @default.
• W2063278306 cites W1969989471 @default.
• W2063278306 cites W1970102973 @default.
• W2063278306 cites W1971432878 @default.
• W2063278306 cites W1973581229 @default.
• W2063278306 cites W1974387854 @default.
• W2063278306 cites W1977500429 @default.
• W2063278306 cites W1977849517 @default.
• W2063278306 cites W1978833848 @default.
• W2063278306 cites W1979034983 @default.
• W2063278306 cites W1981275799 @default.
• W2063278306 cites W1981558598 @default.
• W2063278306 cites W1982814832 @default.
• W2063278306 cites W1983639236 @default.
• W2063278306 cites W1983746990 @default.
• W2063278306 cites W1985498374 @default.
• W2063278306 cites W1985582613 @default.
• W2063278306 cites W1988275850 @default.
• W2063278306 cites W1990331210 @default.
• W2063278306 cites W1996600611 @default.
• W2063278306 cites W1997171401 @default.
• W2063278306 cites W1998325459 @default.
• W2063278306 cites W2001458321 @default.
• W2063278306 cites W2001870632 @default.
• W2063278306 cites W2004156074 @default.
• W2063278306 cites W2006609990 @default.
• W2063278306 cites W2013453209 @default.
• W2063278306 cites W2017851636 @default.
• W2063278306 cites W2018814167 @default.
• W2063278306 cites W2021180718 @default.
• W2063278306 cites W2024995619 @default.
• W2063278306 cites W2030395147 @default.
• W2063278306 cites W2032578858 @default.
• W2063278306 cites W2034207986 @default.
• W2063278306 cites W2042091458 @default.
• W2063278306 cites W2046336824 @default.
• W2063278306 cites W2046817311 @default.
• W2063278306 cites W2048937194 @default.
• W2063278306 cites W2050717100 @default.
• W2063278306 cites W2050783266 @default.
• W2063278306 cites W2053323620 @default.
• W2063278306 cites W2056162837 @default.
• W2063278306 cites W2056967782 @default.
• W2063278306 cites W2058713030 @default.
• W2063278306 cites W2061359205 @default.
• W2063278306 cites W2063012995 @default.
• W2063278306 cites W2063237661 @default.
• W2063278306 cites W2063763265 @default.
• W2063278306 cites W2067363410 @default.
• W2063278306 cites W2071072403 @default.
• W2063278306 cites W2071634031 @default.
• W2063278306 cites W2071714163 @default.
• W2063278306 cites W2071881327 @default.
• W2063278306 cites W2076702034 @default.
• W2063278306 cites W2077321554 @default.
• W2063278306 cites W2078057335 @default.
• W2063278306 cites W2078617761 @default.
• W2063278306 cites W2081372392 @default.
• W2063278306 cites W2082988068 @default.
• W2063278306 cites W2090488508 @default.
• W2063278306 cites W2092631377 @default.
• W2063278306 cites W2092714197 @default.
• W2063278306 cites W2094897512 @default.
• W2063278306 cites W2099286545 @default.
• W2063278306 cites W2101290162 @default.
• W2063278306 cites W2103685054 @default.
• W2063278306 cites W2114104729 @default.
• W2063278306 cites W2116649573 @default.
• W2063278306 cites W2119072846 @default.
• W2063278306 cites W2136709687 @default.
• W2063278306 cites W2145737112 @default.
• W2063278306 cites W2149141821 @default.
• W2063278306 cites W4322703309 @default.
• W2063278306 doi "https://doi.org/10.1016/j.neuroscience.2005.02.018" @default.
• W2063278306 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15893653" @default.
• W2063278306 hasPublicationYear "2005" @default.
• W2063278306 type Work @default.
• W2063278306 sameAs 2063278306 @default.
• W2063278306 citedByCount "31" @default.
• W2063278306 countsByYear W20632783062014 @default.
• W2063278306 countsByYear W20632783062017 @default.
• W2063278306 countsByYear W20632783062019 @default.

• next