Matches in SemOpenAlex for { <https://semopenalex.org/work/W2063279866> ?p ?o ?g. }
- W2063279866 endingPage "53" @default.
- W2063279866 startingPage "53" @default.
- W2063279866 abstract "Anorexia nervosa versus hyperinsulinism: therapeutic effects of neuropharmacological manipulation Fuad Lechin1,2, Bertha van der Dijs1,2, Betty Pardey-Maldonado1, Scarlet Baez1, Marcel E Lechin31Sections of Neuroendocrinology, Neuropharmacology, and Neurochemistry, Department of Pathophysiology, Institute of Experimental Medicine, Faculty of Medicine, Universidad Central de Venezuela, Caracas; 2Instituto de Vias Digestivas Caracas, Centro Clínico Profesional Caracas, Venezuela; 3Department of Internal Medicine, Texas A & M Health Science Center, College of Medicine, Texas, USABackground: We have demonstrated that anorexia nervosa is underpinned by overwhelming adrenal sympathetic activity which abolishes the neural sympathetic branch of the peripheral autonomic nervous system. This physiological disorder is responsible for gastrointestinal hypomotility, hyperglycemia, raised systolic blood pressure, raised heart rate, and other neuroendocrine disorders. Therefore, we prescribed neuropharmacological therapy to reverse this central and autonomic nervous system disorder, in order to normalize the clinical and neuroendocrine profile.Methods: The study included 22 female patients with anorexia nervosa (10 restricted type, 12 binge-eating type) who received three months of treatment with amantadine 100 mg/day. We measured blood pressure, heart rate, and circulating neurotransmitters, (noradrenaline, adrenaline, dopamine, platelet serotonin, free plasma serotonin) during supine resting, one minute of orthostasis, and a five-minute exercise test before and after one, two, and three months of treatment with amantadine, a drug which abrogates adrenal sympathetic activity by acting at the C1(Ad) medullary nuclei responsible for this branch of the peripheral sympathetic activity.Results: We found the amantadine abolished symptoms of anorexia nervosa from the first oral dose onwards. Normalization of autonomic and cardiovascular parameters was demonstrated within the early days of therapy. Abrupt and sustained increases in the plasma noradrenaline:adrenaline ratio and disappearance of abnormal plasma glucose elevation were registered throughout the three-month duration of the trial. Significant and sustained increases in body weight were documented in all cases. No relapses were observed.Conclusion: We have confirmed our previously published findings showing that the anorexia nervosa syndrome depends on the hypomotility of the gastrointestinal tract plus hyperglycemia, both of which are triggered by adrenal sympathetic hyperactivity. The above neuroendocrine plus neuroautonomic and clinical disorders which underpinned anorexia nervosa were abruptly suppressed since the first oral dose of amantadine, a drug able to revert the C1(Ad) over A5(NA) pontomedullary predominance responsible for adrenal and neural sympathetic activity, respectively. Keywords: amantadine, anorexia nervosa, adrenal sympathetic activity, hyperglycemia, hyperinsulinism, neural sympathetic activity" @default.
- W2063279866 created "2016-06-24" @default.
- W2063279866 creator A5017722758 @default.
- W2063279866 creator A5037006002 @default.
- W2063279866 creator A5073092661 @default.
- W2063279866 creator A5090147603 @default.
- W2063279866 creator A5091474071 @default.
- W2063279866 date "2011-02-01" @default.
- W2063279866 modified "2023-10-01" @default.
- W2063279866 title "Anorexia nervosa versus hyperinsulinism: therapeutic effects of neuropharmacological manipulation" @default.
- W2063279866 cites W1587475087 @default.
- W2063279866 cites W1943576895 @default.
- W2063279866 cites W1968006751 @default.
- W2063279866 cites W1973847766 @default.
- W2063279866 cites W1980794246 @default.
- W2063279866 cites W1980925491 @default.
- W2063279866 cites W1998212627 @default.
- W2063279866 cites W2003181805 @default.
- W2063279866 cites W2006768518 @default.
- W2063279866 cites W2009033131 @default.
- W2063279866 cites W2019593839 @default.
- W2063279866 cites W2020626736 @default.
- W2063279866 cites W2034303957 @default.
- W2063279866 cites W2046415667 @default.
- W2063279866 cites W2048248550 @default.
- W2063279866 cites W2052997914 @default.
- W2063279866 cites W2053590245 @default.
- W2063279866 cites W2075477638 @default.
- W2063279866 cites W2078908114 @default.
- W2063279866 cites W2079687627 @default.
- W2063279866 cites W2090695956 @default.
- W2063279866 cites W2091023362 @default.
- W2063279866 cites W2093645564 @default.
- W2063279866 cites W2095168866 @default.
- W2063279866 cites W2100281789 @default.
- W2063279866 cites W2135514207 @default.
- W2063279866 cites W2168311566 @default.
- W2063279866 cites W2409062267 @default.
- W2063279866 cites W2413965494 @default.
- W2063279866 doi "https://doi.org/10.2147/tcrm.s16958" @default.
- W2063279866 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3061844" @default.
- W2063279866 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21445279" @default.
- W2063279866 hasPublicationYear "2011" @default.
- W2063279866 type Work @default.
- W2063279866 sameAs 2063279866 @default.
- W2063279866 citedByCount "6" @default.
- W2063279866 countsByYear W20632798662016 @default.
- W2063279866 countsByYear W20632798662019 @default.
- W2063279866 countsByYear W20632798662021 @default.
- W2063279866 countsByYear W20632798662022 @default.
- W2063279866 countsByYear W20632798662023 @default.
- W2063279866 crossrefType "journal-article" @default.
- W2063279866 hasAuthorship W2063279866A5017722758 @default.
- W2063279866 hasAuthorship W2063279866A5037006002 @default.
- W2063279866 hasAuthorship W2063279866A5073092661 @default.
- W2063279866 hasAuthorship W2063279866A5090147603 @default.
- W2063279866 hasAuthorship W2063279866A5091474071 @default.
- W2063279866 hasBestOaLocation W20632798661 @default.
- W2063279866 hasConcept C118552586 @default.
- W2063279866 hasConcept C126322002 @default.
- W2063279866 hasConcept C134018914 @default.
- W2063279866 hasConcept C2776394216 @default.
- W2063279866 hasConcept C2777031586 @default.
- W2063279866 hasConcept C2777372248 @default.
- W2063279866 hasConcept C2777374534 @default.
- W2063279866 hasConcept C2777953023 @default.
- W2063279866 hasConcept C71924100 @default.
- W2063279866 hasConcept C84393581 @default.
- W2063279866 hasConcept C98274493 @default.
- W2063279866 hasConceptScore W2063279866C118552586 @default.
- W2063279866 hasConceptScore W2063279866C126322002 @default.
- W2063279866 hasConceptScore W2063279866C134018914 @default.
- W2063279866 hasConceptScore W2063279866C2776394216 @default.
- W2063279866 hasConceptScore W2063279866C2777031586 @default.
- W2063279866 hasConceptScore W2063279866C2777372248 @default.
- W2063279866 hasConceptScore W2063279866C2777374534 @default.
- W2063279866 hasConceptScore W2063279866C2777953023 @default.
- W2063279866 hasConceptScore W2063279866C71924100 @default.
- W2063279866 hasConceptScore W2063279866C84393581 @default.
- W2063279866 hasConceptScore W2063279866C98274493 @default.
- W2063279866 hasLocation W20632798661 @default.
- W2063279866 hasLocation W20632798662 @default.
- W2063279866 hasLocation W20632798663 @default.
- W2063279866 hasLocation W20632798664 @default.
- W2063279866 hasOpenAccess W2063279866 @default.
- W2063279866 hasPrimaryLocation W20632798661 @default.
- W2063279866 hasRelatedWork W138949052 @default.
- W2063279866 hasRelatedWork W2013390902 @default.
- W2063279866 hasRelatedWork W2021868940 @default.
- W2063279866 hasRelatedWork W2056435782 @default.
- W2063279866 hasRelatedWork W2067845550 @default.
- W2063279866 hasRelatedWork W2072606746 @default.
- W2063279866 hasRelatedWork W2472298192 @default.
- W2063279866 hasRelatedWork W2541220338 @default.
- W2063279866 hasRelatedWork W2553635862 @default.
- W2063279866 hasRelatedWork W2606977046 @default.
- W2063279866 isParatext "false" @default.
- W2063279866 isRetracted "false" @default.