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W2063286341 abstract "Long-term intrathecal drug administration using implanted pumps is increasingly used in the treatment of chronic refractory pain [Anderson and Burchiel 1999, Neurosurgery 44 (1999) 289; Krames 2002, Best Pract Res Clin Anaesthesiol 16 (2002) 619; Wallace 2002, Neurology 59 (2002) S18]. Extensive clinical experience over the last 15 years suggests that in selected cases the technique is safe, although infections, system malfunction and drug-related complications have been reported. In most cases, drug-related spinal cord injuries have resulted from the compression of a spinal inflammatory mass or abcess rather than from a direct neurotoxic effect. We report on a case of toxic spinal cord lesion occurring after more than 3 years of uneventful continuous infusion of a mixture of bupivacaine and clonidine." @default.
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W2063286341 date "2004-05-01" @default.
W2063286341 modified "2023-10-17" @default.
W2063286341 title "Spinal cord lesion after long-term intrathecal clonidine and bupivacaine treatment for the management of intractable pain" @default.
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W2063286341 doi "https://doi.org/10.1016/j.pain.2003.11.001" @default.
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