FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2063311747> ?p ?o ?g. }

• W2063311747 abstract "The discovery of causal mutations in the low-density lipoprotein receptor-related protein 5 (LRP5) gene underlying conditions of altered bone mass ushered in a new era in bone research. Since those original publications, the role of Lrp5 and the Wnt/β-catenin signaling pathway controlled by Lrp5 and its homologs, Lrp6 and Lrp4, in bone mass regulation has been an intense area of investigation. Studies to date have implicated this pathway in skeletal development, osteoblast differentiation and proliferation, osteoblast/osteocyte apoptosis, regulation of the balance between osteogenesis-chondrogenesis-adipogenesis, regulation of osteoclastogenesis and the response of bone to mechanical loading. Interestingly, the data from knockout and transgenic mice involving Lrp4/5/6 and/or their regulators, as well as β-catenin signaling pathway components, and in vitro studies have sometimes yielded conflicting results. Adding to the complexity of the system are the studies that suggested Lrp5 regulated bone mass through a gut-bone endocrine signaling system involving Lrp5 mediated control of gut serotonin synthesis. However, recent studies have called this into question and so this provocative concept remains an open question. Clearly, the manipulation of Lrp5/Wnt/β-catenin pathway presents as a major target for drug development to treat diseases of low bone mass such as osteoporosis and these new therapies are in full progress. At present, although it is clear that Lrp5 has a role in bone mass regulation, much of the details remain to be elucidated and this is a major and exciting challenge for future studies." @default.
• W2063311747 created "2016-06-24" @default.
• W2063311747 creator A5060693982 @default.
• W2063311747 date "2012-01-10" @default.
• W2063311747 modified "2023-09-25" @default.
• W2063311747 title "LRP5 and bone mass regulation: Where are we now?" @default.
• W2063311747 cites W1611720630 @default.
• W2063311747 cites W1912211224 @default.
• W2063311747 cites W1970854913 @default.
• W2063311747 cites W1974315061 @default.
• W2063311747 cites W1979775212 @default.
• W2063311747 cites W1981199578 @default.
• W2063311747 cites W1981284961 @default.
• W2063311747 cites W1981591594 @default.
• W2063311747 cites W1983220846 @default.
• W2063311747 cites W1984332525 @default.
• W2063311747 cites W1988065037 @default.
• W2063311747 cites W1989215255 @default.
• W2063311747 cites W1989724036 @default.
• W2063311747 cites W1990495894 @default.
• W2063311747 cites W1991122717 @default.
• W2063311747 cites W1993163869 @default.
• W2063311747 cites W1997588694 @default.
• W2063311747 cites W1999322873 @default.
• W2063311747 cites W1999418860 @default.
• W2063311747 cites W2002073678 @default.
• W2063311747 cites W2002272803 @default.
• W2063311747 cites W2004680594 @default.
• W2063311747 cites W2009967392 @default.
• W2063311747 cites W2011828467 @default.
• W2063311747 cites W2013293643 @default.
• W2063311747 cites W2014362480 @default.
• W2063311747 cites W2017802249 @default.
• W2063311747 cites W2017877350 @default.
• W2063311747 cites W2024679248 @default.
• W2063311747 cites W2025087598 @default.
• W2063311747 cites W2026533505 @default.
• W2063311747 cites W2027381107 @default.
• W2063311747 cites W2036120792 @default.
• W2063311747 cites W2038059821 @default.
• W2063311747 cites W2041181827 @default.
• W2063311747 cites W2043224349 @default.
• W2063311747 cites W2044350451 @default.
• W2063311747 cites W2045520966 @default.
• W2063311747 cites W2056301653 @default.
• W2063311747 cites W2064676044 @default.
• W2063311747 cites W2065335638 @default.
• W2063311747 cites W2066869961 @default.
• W2063311747 cites W2067864034 @default.
• W2063311747 cites W2073052871 @default.
• W2063311747 cites W2073907573 @default.
• W2063311747 cites W2073952925 @default.
• W2063311747 cites W2078883007 @default.
• W2063311747 cites W2081704147 @default.
• W2063311747 cites W2082725529 @default.
• W2063311747 cites W2084226723 @default.
• W2063311747 cites W2086694435 @default.
• W2063311747 cites W2088466503 @default.
• W2063311747 cites W2090636859 @default.
• W2063311747 cites W2093317619 @default.
• W2063311747 cites W2096007284 @default.
• W2063311747 cites W2102175769 @default.
• W2063311747 cites W2103412450 @default.
• W2063311747 cites W2103581668 @default.
• W2063311747 cites W2103737135 @default.
• W2063311747 cites W2105054202 @default.
• W2063311747 cites W2110838173 @default.
• W2063311747 cites W2116610925 @default.
• W2063311747 cites W2119413986 @default.
• W2063311747 cites W2122155371 @default.
• W2063311747 cites W2123346255 @default.
• W2063311747 cites W2130351976 @default.
• W2063311747 cites W2137395552 @default.
• W2063311747 cites W2139710747 @default.
• W2063311747 cites W2140544512 @default.
• W2063311747 cites W2144226194 @default.
• W2063311747 cites W2146138547 @default.
• W2063311747 cites W2155984559 @default.
• W2063311747 cites W2156500310 @default.
• W2063311747 cites W2159374159 @default.
• W2063311747 cites W2159406891 @default.
• W2063311747 cites W2163341100 @default.
• W2063311747 cites W2171967326 @default.
• W2063311747 cites W2322740946 @default.
• W2063311747 cites W2329566337 @default.
• W2063311747 doi "https://doi.org/10.1038/bonekey.2012.1" @default.
• W2063311747 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3705993" @default.
• W2063311747 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23951413" @default.
• W2063311747 hasPublicationYear "2012" @default.
• W2063311747 type Work @default.
• W2063311747 sameAs 2063311747 @default.
• W2063311747 citedByCount "22" @default.
• W2063311747 countsByYear W20633117472012 @default.
• W2063311747 countsByYear W20633117472013 @default.
• W2063311747 countsByYear W20633117472014 @default.
• W2063311747 countsByYear W20633117472016 @default.
• W2063311747 countsByYear W20633117472017 @default.
• W2063311747 countsByYear W20633117472018 @default.
• W2063311747 countsByYear W20633117472019 @default.
• W2063311747 countsByYear W20633117472021 @default.

• next