Matches in SemOpenAlex for { <https://semopenalex.org/work/W2063329630> ?p ?o ?g. }
Showing items 1 to 77 of
77
with 100 items per page.
- W2063329630 endingPage "167" @default.
- W2063329630 startingPage "162" @default.
- W2063329630 abstract "The relative rates of hepatic 3H incorporation into digitonin-precipitable sterols (DPS) and release of labeled DPS into the plasma were compared between copper-deficient (CuD) and copper-adequate (CuA) rats. Following intravenous injection of 3H2O and Triton WR 1339, the liver and plasma 3H-DPS radioactivities were measured at 2, 4, 6, and 8 hr, and the net total accumulation of plasma cholesterol (CH) and triglyceride (TG) was determined during the 8-hr period. In both groups, the liver synthesis of 3H-DPS displayed a biphasic curve, with an initial slow rate up to 4 hr, followed by a rapid increase starting at 6 hr. During the latter phase, a notable increase in liver 3H-DPS radioactivity was observed in CuD rats, but the plasma release of 3H-DPS did not significantly change, despite the increased synthesis of 3H-DPS in the liver. In both groups, the net total accumulation of CH in the plasma, as expressed in mmol CH/100 g body weight, increased steadily from 1.2 mmol at 2 hr to 4.7 mmol at 8 hr, while plasma TG accumulated at a much greater rate ranging from 3.3 mmol at 2 hr to 13.6 mmol at 8 hr. There was no significant difference in net total accumulation of CH or Tg in the plasma between the groups at any given interval. The results provide evidence that copper deficiency stimulates the liver synthesis of cholesterol, but that it does not result in an accelerated release of newly synthesized cholesterol from the liver involving very low density lipoproteins (VLDL). Thus, the present findings suggest that the hypercholesterolemia induced in copper deficiency is not attributable to a stimulation of the hepatic release of VLDL cholesterol into the plasma." @default.
- W2063329630 created "2016-06-24" @default.
- W2063329630 creator A5050132145 @default.
- W2063329630 creator A5054842109 @default.
- W2063329630 creator A5083962152 @default.
- W2063329630 date "1993-03-01" @default.
- W2063329630 modified "2023-09-23" @default.
- W2063329630 title "Effect of copper deficiency on the hepatic synthesis and rate of plasma release of cholesterol," @default.
- W2063329630 cites W1491843388 @default.
- W2063329630 cites W1581336589 @default.
- W2063329630 cites W1802412865 @default.
- W2063329630 cites W1926017808 @default.
- W2063329630 cites W1940943995 @default.
- W2063329630 cites W1946263363 @default.
- W2063329630 cites W2013500458 @default.
- W2063329630 cites W2017471941 @default.
- W2063329630 cites W2021354995 @default.
- W2063329630 cites W2025450317 @default.
- W2063329630 cites W2050870648 @default.
- W2063329630 cites W2065250513 @default.
- W2063329630 cites W2066030167 @default.
- W2063329630 cites W2089982116 @default.
- W2063329630 cites W2118313918 @default.
- W2063329630 cites W2139618227 @default.
- W2063329630 cites W2187020408 @default.
- W2063329630 cites W2313943602 @default.
- W2063329630 cites W2324557299 @default.
- W2063329630 cites W2397594219 @default.
- W2063329630 cites W2417212854 @default.
- W2063329630 doi "https://doi.org/10.1016/0955-2863(93)90045-x" @default.
- W2063329630 hasPublicationYear "1993" @default.
- W2063329630 type Work @default.
- W2063329630 sameAs 2063329630 @default.
- W2063329630 citedByCount "3" @default.
- W2063329630 crossrefType "journal-article" @default.
- W2063329630 hasAuthorship W2063329630A5050132145 @default.
- W2063329630 hasAuthorship W2063329630A5054842109 @default.
- W2063329630 hasAuthorship W2063329630A5083962152 @default.
- W2063329630 hasConcept C126322002 @default.
- W2063329630 hasConcept C134018914 @default.
- W2063329630 hasConcept C185592680 @default.
- W2063329630 hasConcept C2776575606 @default.
- W2063329630 hasConcept C2778163477 @default.
- W2063329630 hasConcept C2778913445 @default.
- W2063329630 hasConcept C55493867 @default.
- W2063329630 hasConcept C71924100 @default.
- W2063329630 hasConcept C86803240 @default.
- W2063329630 hasConceptScore W2063329630C126322002 @default.
- W2063329630 hasConceptScore W2063329630C134018914 @default.
- W2063329630 hasConceptScore W2063329630C185592680 @default.
- W2063329630 hasConceptScore W2063329630C2776575606 @default.
- W2063329630 hasConceptScore W2063329630C2778163477 @default.
- W2063329630 hasConceptScore W2063329630C2778913445 @default.
- W2063329630 hasConceptScore W2063329630C55493867 @default.
- W2063329630 hasConceptScore W2063329630C71924100 @default.
- W2063329630 hasConceptScore W2063329630C86803240 @default.
- W2063329630 hasIssue "3" @default.
- W2063329630 hasLocation W20633296301 @default.
- W2063329630 hasOpenAccess W2063329630 @default.
- W2063329630 hasPrimaryLocation W20633296301 @default.
- W2063329630 hasRelatedWork W2013998010 @default.
- W2063329630 hasRelatedWork W2020423440 @default.
- W2063329630 hasRelatedWork W2023333646 @default.
- W2063329630 hasRelatedWork W2029959808 @default.
- W2063329630 hasRelatedWork W2035484352 @default.
- W2063329630 hasRelatedWork W2068269311 @default.
- W2063329630 hasRelatedWork W2070290955 @default.
- W2063329630 hasRelatedWork W2086159102 @default.
- W2063329630 hasRelatedWork W2110966479 @default.
- W2063329630 hasRelatedWork W2350174576 @default.
- W2063329630 hasVolume "4" @default.
- W2063329630 isParatext "false" @default.
- W2063329630 isRetracted "false" @default.
- W2063329630 magId "2063329630" @default.
- W2063329630 workType "article" @default.