FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2063340830> ?p ?o ?g. }

• W2063340830 endingPage "36" @default.
• W2063340830 startingPage "25" @default.
• W2063340830 abstract "This study was conducted to gain an understanding of the enhancement mechanism of fatty acids in skin permeation of physostigmine (PHY) by using a series of fatty acids and two solvents of opposing lipophilicity (propylene glycol (PG) and mineral oil (MO)). Interaction between fatty acid and drug was proven using NMR and conductivity measurements that showed a dependence on type of solvent used. Permeation flux of physostigmine from mineral oil-based formulations to skin was increased as solubility of physostigmine in mineral oil was enhanced in the presence of fatty acids having a longer chain. Thus, the dominant role of fatty acids in mineral oil was to increase solubility of physostigmine in the formulations that increased the driving force for physostigmine permeation through skin. As for propylene glycol, enhancement caused by fatty acids was attributed to their ability to increase the lipophilicity of formulation and to disrupt the lipid bilayers within the stratum corneum (SC). In conclusion, fatty acids enhancement for drug permeation across the skin was found to be dependent on the solvent used. Among various formulations here, oleic acid in mineral oil yielded fast permeation of PHY with a short lag time, which may be a good vehicle for transdermal delivery of PHY." @default.
• W2063340830 created "2016-06-24" @default.
• W2063340830 creator A5007273654 @default.
• W2063340830 creator A5020074724 @default.
• W2063340830 creator A5061533820 @default.
• W2063340830 date "2005-02-01" @default.
• W2063340830 modified "2023-09-27" @default.
• W2063340830 title "Skin permeation of physostigmine from fatty acids-based formulations: evaluating the choice of solvent" @default.
• W2063340830 cites W1495654615 @default.
• W2063340830 cites W1508026543 @default.
• W2063340830 cites W1515777772 @default.
• W2063340830 cites W1550353272 @default.
• W2063340830 cites W1983028379 @default.
• W2063340830 cites W1984348385 @default.
• W2063340830 cites W1985052832 @default.
• W2063340830 cites W1991575888 @default.
• W2063340830 cites W2015500107 @default.
• W2063340830 cites W2016082474 @default.
• W2063340830 cites W2023439288 @default.
• W2063340830 cites W2029066829 @default.
• W2063340830 cites W2031455555 @default.
• W2063340830 cites W2034475816 @default.
• W2063340830 cites W2053828559 @default.
• W2063340830 cites W2056411340 @default.
• W2063340830 cites W2062704583 @default.
• W2063340830 cites W2071357405 @default.
• W2063340830 cites W2075145360 @default.
• W2063340830 cites W2079859568 @default.
• W2063340830 cites W2158216542 @default.
• W2063340830 cites W2166507033 @default.
• W2063340830 cites W316775343 @default.
• W2063340830 doi "https://doi.org/10.1016/j.ijpharm.2004.10.027" @default.
• W2063340830 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15664127" @default.
• W2063340830 hasPublicationYear "2005" @default.
• W2063340830 type Work @default.
• W2063340830 sameAs 2063340830 @default.
• W2063340830 citedByCount "21" @default.
• W2063340830 countsByYear W20633408302012 @default.
• W2063340830 countsByYear W20633408302013 @default.
• W2063340830 countsByYear W20633408302014 @default.
• W2063340830 countsByYear W20633408302020 @default.
• W2063340830 countsByYear W20633408302021 @default.
• W2063340830 countsByYear W20633408302022 @default.
• W2063340830 crossrefType "journal-article" @default.
• W2063340830 hasAuthorship W2063340830A5007273654 @default.
• W2063340830 hasAuthorship W2063340830A5020074724 @default.
• W2063340830 hasAuthorship W2063340830A5061533820 @default.
• W2063340830 hasConcept C142724271 @default.
• W2063340830 hasConcept C155574463 @default.
• W2063340830 hasConcept C178790620 @default.
• W2063340830 hasConcept C185592680 @default.
• W2063340830 hasConcept C201399114 @default.
• W2063340830 hasConcept C2775910092 @default.
• W2063340830 hasConcept C2776663719 @default.
• W2063340830 hasConcept C2778370115 @default.
• W2063340830 hasConcept C2779977313 @default.
• W2063340830 hasConcept C2780471494 @default.
• W2063340830 hasConcept C2781403372 @default.
• W2063340830 hasConcept C41625074 @default.
• W2063340830 hasConcept C43617362 @default.
• W2063340830 hasConcept C50670333 @default.
• W2063340830 hasConcept C543025807 @default.
• W2063340830 hasConcept C55493867 @default.
• W2063340830 hasConcept C71924100 @default.
• W2063340830 hasConcept C98274493 @default.
• W2063340830 hasConceptScore W2063340830C142724271 @default.
• W2063340830 hasConceptScore W2063340830C155574463 @default.
• W2063340830 hasConceptScore W2063340830C178790620 @default.
• W2063340830 hasConceptScore W2063340830C185592680 @default.
• W2063340830 hasConceptScore W2063340830C201399114 @default.
• W2063340830 hasConceptScore W2063340830C2775910092 @default.
• W2063340830 hasConceptScore W2063340830C2776663719 @default.
• W2063340830 hasConceptScore W2063340830C2778370115 @default.
• W2063340830 hasConceptScore W2063340830C2779977313 @default.
• W2063340830 hasConceptScore W2063340830C2780471494 @default.
• W2063340830 hasConceptScore W2063340830C2781403372 @default.
• W2063340830 hasConceptScore W2063340830C41625074 @default.
• W2063340830 hasConceptScore W2063340830C43617362 @default.
• W2063340830 hasConceptScore W2063340830C50670333 @default.
• W2063340830 hasConceptScore W2063340830C543025807 @default.
• W2063340830 hasConceptScore W2063340830C55493867 @default.
• W2063340830 hasConceptScore W2063340830C71924100 @default.
• W2063340830 hasConceptScore W2063340830C98274493 @default.
• W2063340830 hasIssue "1-2" @default.
• W2063340830 hasLocation W20633408301 @default.
• W2063340830 hasLocation W20633408302 @default.
• W2063340830 hasOpenAccess W2063340830 @default.
• W2063340830 hasPrimaryLocation W20633408301 @default.
• W2063340830 hasRelatedWork W2031455555 @default.
• W2063340830 hasRelatedWork W2059169882 @default.
• W2063340830 hasRelatedWork W2063340830 @default.
• W2063340830 hasRelatedWork W2070257094 @default.
• W2063340830 hasRelatedWork W2075924628 @default.
• W2063340830 hasRelatedWork W2112847170 @default.
• W2063340830 hasRelatedWork W2149381475 @default.
• W2063340830 hasRelatedWork W2149577404 @default.
• W2063340830 hasRelatedWork W2187794848 @default.
• W2063340830 hasRelatedWork W2786905752 @default.

• next