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• W2063342103 abstract "Morphine modulates neuronal and immune cell functions via μ-opioid receptors. In primary and Jurkat T cells, and Raji B cells μ-opioid receptor transcripts were detected only after stimulation of the cells with IL-4 or TNF-α. Moreover, the amount of the induced μ-opioid receptor mRNA in the immune cells was 15 to 200 times less than those in primary cortical and SH SY5Y neuronal cells. Nevertheless, μ-opioid receptor mRNA in immune cells is processed to functional receptors, as demonstrated by morphine-mediated phosphorylation of mitogen activated protein kinase, morphine-mediated up-regulation of IL-4 mRNA and coupling to adenylyl cyclase in Jurkat cells." @default.
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• W2063342103 date "2007-08-01" @default.
• W2063342103 modified "2023-09-25" @default.
• W2063342103 title "Comparative analysis of mu-opioid receptor expression in immune and neuronal cells" @default.
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• W2063342103 doi "https://doi.org/10.1016/j.jneuroim.2007.05.007" @default.
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