FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2063343795> ?p ?o ?g. }

• W2063343795 endingPage "2234" @default.
• W2063343795 startingPage "2229" @default.
• W2063343795 abstract "With advent of several treatment options in multiple myeloma (MM), a selection of effective regimen has become an important issue. Use of gene expression profile (GEP) is considered an important tool in predicting outcome; however, it is unclear whether such genomic analysis alone can adequately predict therapeutic response. We evaluated the ability of GEP to predict complete response (CR) in MM. GEP from pretreatment MM cells from 136 uniformly treated MM patients with response data on an IFM, France led study were analyzed. To evaluate variability in predictive power due to microarray platform or treatment types, additional data sets from three different studies (n=511) were analyzed using same methods. We used several machine learning methods to derive a prediction model using training and test subsets of the original four data sets. Among all methods employed for GEP-based CR predictive capability, we got accuracy range of 56–78% in test data sets and no significant difference with regard to GEP platforms, treatment regimens or in newly diagnosed or relapsed patients. Importantly, permuted P-value showed no statistically significant CR predictive information in GEP data. This analysis suggests that GEP-based signature has limited power to predict CR in MM, highlighting the need to develop comprehensive predictive model using integrated genomics approach." @default.
• W2063343795 created "2016-06-24" @default.
• W2063343795 creator A5002972322 @default.
• W2063343795 creator A5003019326 @default.
• W2063343795 creator A5003294000 @default.
• W2063343795 creator A5011827756 @default.
• W2063343795 creator A5012908005 @default.
• W2063343795 creator A5032464400 @default.
• W2063343795 creator A5038883988 @default.
• W2063343795 creator A5040082277 @default.
• W2063343795 creator A5041002394 @default.
• W2063343795 creator A5044349591 @default.
• W2063343795 creator A5045740077 @default.
• W2063343795 creator A5057939952 @default.
• W2063343795 creator A5064842058 @default.
• W2063343795 creator A5067080931 @default.
• W2063343795 creator A5080712446 @default.
• W2063343795 creator A5083724705 @default.
• W2063343795 creator A5089637265 @default.
• W2063343795 date "2014-04-15" @default.
• W2063343795 modified "2023-10-14" @default.
• W2063343795 title "Gene expression profile alone is inadequate in predicting complete response in multiple myeloma" @default.
• W2063343795 cites W1765663453 @default.
• W2063343795 cites W1977691688 @default.
• W2063343795 cites W1978377409 @default.
• W2063343795 cites W1978443443 @default.
• W2063343795 cites W1988893055 @default.
• W2063343795 cites W1995246165 @default.
• W2063343795 cites W1997001746 @default.
• W2063343795 cites W2000189234 @default.
• W2063343795 cites W2006633259 @default.
• W2063343795 cites W2010552629 @default.
• W2063343795 cites W2019564182 @default.
• W2063343795 cites W2020234719 @default.
• W2063343795 cites W2023560584 @default.
• W2063343795 cites W2024123206 @default.
• W2063343795 cites W2032640560 @default.
• W2063343795 cites W2038437697 @default.
• W2063343795 cites W2043235003 @default.
• W2063343795 cites W2048381552 @default.
• W2063343795 cites W2050991415 @default.
• W2063343795 cites W2059581635 @default.
• W2063343795 cites W2064601405 @default.
• W2063343795 cites W2069548171 @default.
• W2063343795 cites W2087843841 @default.
• W2063343795 cites W2098603697 @default.
• W2063343795 cites W2104195581 @default.
• W2063343795 cites W2109936378 @default.
• W2063343795 cites W2110183976 @default.
• W2063343795 cites W2115028783 @default.
• W2063343795 cites W2119462367 @default.
• W2063343795 cites W2120929463 @default.
• W2063343795 cites W2125721471 @default.
• W2063343795 cites W2128012941 @default.
• W2063343795 cites W2128084036 @default.
• W2063343795 cites W2136810538 @default.
• W2063343795 cites W2137388109 @default.
• W2063343795 cites W2144930991 @default.
• W2063343795 cites W2146263996 @default.
• W2063343795 cites W2146578910 @default.
• W2063343795 cites W2147894577 @default.
• W2063343795 cites W2150997370 @default.
• W2063343795 cites W2152333590 @default.
• W2063343795 cites W2155165473 @default.
• W2063343795 cites W2155612034 @default.
• W2063343795 cites W2157936723 @default.
• W2063343795 cites W2158470148 @default.
• W2063343795 cites W2162180804 @default.
• W2063343795 cites W2163999353 @default.
• W2063343795 cites W2165974443 @default.
• W2063343795 cites W2171504422 @default.
• W2063343795 cites W2204196185 @default.
• W2063343795 cites W2591802441 @default.
• W2063343795 cites W4245776345 @default.
• W2063343795 cites W4251947775 @default.
• W2063343795 cites W947671513 @default.
• W2063343795 doi "https://doi.org/10.1038/leu.2014.140" @default.
• W2063343795 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4198516" @default.
• W2063343795 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24732597" @default.
• W2063343795 hasPublicationYear "2014" @default.
• W2063343795 type Work @default.
• W2063343795 sameAs 2063343795 @default.
• W2063343795 citedByCount "58" @default.
• W2063343795 countsByYear W20633437952014 @default.
• W2063343795 countsByYear W20633437952015 @default.
• W2063343795 countsByYear W20633437952016 @default.
• W2063343795 countsByYear W20633437952017 @default.
• W2063343795 countsByYear W20633437952018 @default.
• W2063343795 countsByYear W20633437952019 @default.
• W2063343795 countsByYear W20633437952020 @default.
• W2063343795 countsByYear W20633437952021 @default.
• W2063343795 countsByYear W20633437952022 @default.
• W2063343795 crossrefType "journal-article" @default.
• W2063343795 hasAuthorship W2063343795A5002972322 @default.
• W2063343795 hasAuthorship W2063343795A5003019326 @default.
• W2063343795 hasAuthorship W2063343795A5003294000 @default.
• W2063343795 hasAuthorship W2063343795A5011827756 @default.
• W2063343795 hasAuthorship W2063343795A5012908005 @default.

• next