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• W2063350956 abstract "MRP2 encoded by ABCC2 gene is involved in the secretion of numerous drugs and endogenous substrates. Patients with Dubin-Johnson syndrome due to mutation in ABCC2 gene have elevated urinary coproporphyrin ratio (UCP I/(I + III)). Here we investigated whether this ratio could serve as a biomarker of MRP2 function. Phenotype-genotype relationships were studied in 74 healthy subjects by measuring individual UCP I/(I + III) ratio obtained on 24-hour urine and by analyzing five common SNPs in ABCC2 gene. The UCP I/(I + III) ratio varied from 14.7% to 46.0% in our population. Subjects with 3972TT genotype had a higher ratio () than those carrying the C allele. This higher UCP I/(I + III) ratio was correlated with a higher level of isomer I excretion. This study provides a proof of concept that UCP I/(I + III) ratio can be used as a biomarker of MRP2 function in clinical studies as it provides quantitative information about the in vivo activity of MRP2 in a given patient." @default.
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• W2063350956 date "2011-01-01" @default.
• W2063350956 modified "2023-09-30" @default.
• W2063350956 title "Urinary Elimination of Coproporphyrins Is Dependent on<i>ABCC2</i>Polymorphisms and Represents a Potential Biomarker of MRP2 Activity in Humans" @default.
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• W2063350956 doi "https://doi.org/10.1155/2011/498757" @default.
• W2063350956 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3085472" @default.
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