FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2063360864> ?p ?o ?g. }

• W2063360864 endingPage "6116" @default.
• W2063360864 startingPage "6104" @default.
• W2063360864 abstract "CDC5L and PLRG1 are both spliceosomal proteins that are highly conserved across species. They have both been shown to be part of sub‐ spliceosomal protein complexes that are essential for pre‐mRNA splicing in yeast and humans. CDC5L and PLRG1 interact directly in vitro. This interaction is mediated by WD40 regions in PLRG1 and the C‐terminal domain of CDC5L. In order to determine whether this interaction is important for the splicing mechanism, we have designed peptides corresponding to highly conserved sequences in the interaction domains of both proteins. These peptides were used in in vitro splicing experiments as competitors to the cognate sequences in the endogenous proteins. Certain peptides derived from the binding domains of both proteins were found to inhibit in vitro splicing. This splicing inhibition could be prevented by preincubating the peptides with the corresponding partner protein that had been expressed in Escherichia coli. The results from this study indicate that the interaction between CDC5L and PLRG1 is essential for pre‐mRNA splicing and further demonstrate that small peptides can be used as effective splicing inhibitors." @default.
• W2063360864 created "2016-06-24" @default.
• W2063360864 creator A5014112981 @default.
• W2063360864 creator A5068348305 @default.
• W2063360864 date "2003-11-01" @default.
• W2063360864 modified "2023-10-17" @default.
• W2063360864 title "Identification of peptide inhibitors of pre-mRNA splicing derived from the essential interaction domains of CDC5L and PLRG1" @default.
• W2063360864 cites W122323536 @default.
• W2063360864 cites W1546538401 @default.
• W2063360864 cites W1852082707 @default.
• W2063360864 cites W1872026401 @default.
• W2063360864 cites W1907359913 @default.
• W2063360864 cites W1918332224 @default.
• W2063360864 cites W1965137486 @default.
• W2063360864 cites W1973046803 @default.
• W2063360864 cites W1999366805 @default.
• W2063360864 cites W2018289835 @default.
• W2063360864 cites W2021898078 @default.
• W2063360864 cites W2024267851 @default.
• W2063360864 cites W2026372765 @default.
• W2063360864 cites W2027447954 @default.
• W2063360864 cites W2031567993 @default.
• W2063360864 cites W2059804448 @default.
• W2063360864 cites W2073113304 @default.
• W2063360864 cites W2080878856 @default.
• W2063360864 cites W2090312831 @default.
• W2063360864 cites W2100837269 @default.
• W2063360864 cites W2101134838 @default.
• W2063360864 cites W2110090133 @default.
• W2063360864 cites W2117073299 @default.
• W2063360864 cites W2117506397 @default.
• W2063360864 cites W2132505931 @default.
• W2063360864 cites W2165614749 @default.
• W2063360864 cites W2167475869 @default.
• W2063360864 cites W2169345229 @default.
• W2063360864 cites W2186494923 @default.
• W2063360864 doi "https://doi.org/10.1093/nar/gkg817" @default.
• W2063360864 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/275459" @default.
• W2063360864 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14576297" @default.
• W2063360864 hasPublicationYear "2003" @default.
• W2063360864 type Work @default.
• W2063360864 sameAs 2063360864 @default.
• W2063360864 citedByCount "22" @default.
• W2063360864 countsByYear W20633608642012 @default.
• W2063360864 countsByYear W20633608642014 @default.
• W2063360864 countsByYear W20633608642015 @default.
• W2063360864 countsByYear W20633608642016 @default.
• W2063360864 countsByYear W20633608642017 @default.
• W2063360864 countsByYear W20633608642020 @default.
• W2063360864 countsByYear W20633608642021 @default.
• W2063360864 countsByYear W20633608642023 @default.
• W2063360864 crossrefType "journal-article" @default.
• W2063360864 hasAuthorship W2063360864A5014112981 @default.
• W2063360864 hasAuthorship W2063360864A5068348305 @default.
• W2063360864 hasBestOaLocation W20633608641 @default.
• W2063360864 hasConcept C104317684 @default.
• W2063360864 hasConcept C10447831 @default.
• W2063360864 hasConcept C105580179 @default.
• W2063360864 hasConcept C167625842 @default.
• W2063360864 hasConcept C194583182 @default.
• W2063360864 hasConcept C199216141 @default.
• W2063360864 hasConcept C41282012 @default.
• W2063360864 hasConcept C52990999 @default.
• W2063360864 hasConcept C54355233 @default.
• W2063360864 hasConcept C54458228 @default.
• W2063360864 hasConcept C55493867 @default.
• W2063360864 hasConcept C67705224 @default.
• W2063360864 hasConcept C69551769 @default.
• W2063360864 hasConcept C86803240 @default.
• W2063360864 hasConceptScore W2063360864C104317684 @default.
• W2063360864 hasConceptScore W2063360864C10447831 @default.
• W2063360864 hasConceptScore W2063360864C105580179 @default.
• W2063360864 hasConceptScore W2063360864C167625842 @default.
• W2063360864 hasConceptScore W2063360864C194583182 @default.
• W2063360864 hasConceptScore W2063360864C199216141 @default.
• W2063360864 hasConceptScore W2063360864C41282012 @default.
• W2063360864 hasConceptScore W2063360864C52990999 @default.
• W2063360864 hasConceptScore W2063360864C54355233 @default.
• W2063360864 hasConceptScore W2063360864C54458228 @default.
• W2063360864 hasConceptScore W2063360864C55493867 @default.
• W2063360864 hasConceptScore W2063360864C67705224 @default.
• W2063360864 hasConceptScore W2063360864C69551769 @default.
• W2063360864 hasConceptScore W2063360864C86803240 @default.
• W2063360864 hasIssue "21" @default.
• W2063360864 hasLocation W20633608641 @default.
• W2063360864 hasLocation W20633608642 @default.
• W2063360864 hasLocation W20633608643 @default.
• W2063360864 hasLocation W20633608644 @default.
• W2063360864 hasOpenAccess W2063360864 @default.
• W2063360864 hasPrimaryLocation W20633608641 @default.
• W2063360864 hasRelatedWork W1975560388 @default.
• W2063360864 hasRelatedWork W1993816390 @default.
• W2063360864 hasRelatedWork W2026923004 @default.
• W2063360864 hasRelatedWork W2063360864 @default.
• W2063360864 hasRelatedWork W2063946332 @default.
• W2063360864 hasRelatedWork W2073187097 @default.
• W2063360864 hasRelatedWork W2153827965 @default.
• W2063360864 hasRelatedWork W2154700546 @default.

• next