FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2063399228> ?p ?o ?g. }

• W2063399228 endingPage "126" @default.
• W2063399228 startingPage "115" @default.
• W2063399228 abstract "The major mechanism of action of 5-fluorouracil (5FU)-based therapies is thought to be inhibition of thymidylate synthase (TS). This enzyme catalyzes synthesis of the thymidine nucleotide precursor using a methyl group provided by a folate cofactor. In addition to TS activity levels, various elements of methyl-group metabolism could also be predictive for the response of colorectal cancer (CRC) to 5FU. These include the activity of enzymes involved in folate metabolism, the concentrations of intracellular folate intermediates, and surrogate markers of aberrant methyl-group metabolism, such as DNA methylation and microsatellite instability. The factors of age, gender, common genetic variants, and diet have been shown to influence both systemic and tumor methyl-group metabolism. This has important implications for the prediction of toxicity and response to 5FU, respectively. Identification of predictive factors within the methyl-group metabolism pathway should assist in targeting 5FU treatment to the most responsive CRC patient groups. This is particularly important for early-stage disease where conclusive demonstration of a survival benefit from 5FU in the overall CRC group has thus far proven difficult." @default.
• W2063399228 created "2016-06-24" @default.
• W2063399228 creator A5041995242 @default.
• W2063399228 date "2006-01-01" @default.
• W2063399228 modified "2023-10-17" @default.
• W2063399228 title "Methyl-Group Metabolism and the Response of Colorectal Cancer to 5-Fluorouracil" @default.
• W2063399228 cites W1828890888 @default.
• W2063399228 cites W1844681537 @default.
• W2063399228 cites W1845493768 @default.
• W2063399228 cites W1951925296 @default.
• W2063399228 cites W1975800190 @default.
• W2063399228 cites W1984328540 @default.
• W2063399228 cites W1993468897 @default.
• W2063399228 cites W2013784882 @default.
• W2063399228 cites W2051836198 @default.
• W2063399228 cites W2054253574 @default.
• W2063399228 cites W2074279306 @default.
• W2063399228 cites W2094923228 @default.
• W2063399228 cites W2116846790 @default.
• W2063399228 cites W2127951115 @default.
• W2063399228 cites W2130080188 @default.
• W2063399228 cites W2138792383 @default.
• W2063399228 cites W2146643411 @default.
• W2063399228 cites W2148525099 @default.
• W2063399228 cites W2148953497 @default.
• W2063399228 cites W2159848047 @default.
• W2063399228 cites W2165308016 @default.
• W2063399228 cites W2165715420 @default.
• W2063399228 cites W2413536885 @default.
• W2063399228 cites W2469345929 @default.
• W2063399228 doi "https://doi.org/10.1615/critrevoncog.v12.i1-2.60" @default.
• W2063399228 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17078208" @default.
• W2063399228 hasPublicationYear "2006" @default.
• W2063399228 type Work @default.
• W2063399228 sameAs 2063399228 @default.
• W2063399228 citedByCount "9" @default.
• W2063399228 countsByYear W20633992282012 @default.
• W2063399228 countsByYear W20633992282013 @default.
• W2063399228 crossrefType "journal-article" @default.
• W2063399228 hasAuthorship W2063399228A5041995242 @default.
• W2063399228 hasConcept C104317684 @default.
• W2063399228 hasConcept C121608353 @default.
• W2063399228 hasConcept C123321153 @default.
• W2063399228 hasConcept C126322002 @default.
• W2063399228 hasConcept C150194340 @default.
• W2063399228 hasConcept C178790620 @default.
• W2063399228 hasConcept C180754005 @default.
• W2063399228 hasConcept C181199279 @default.
• W2063399228 hasConcept C185592680 @default.
• W2063399228 hasConcept C190727270 @default.
• W2063399228 hasConcept C2778565081 @default.
• W2063399228 hasConcept C2779767149 @default.
• W2063399228 hasConcept C2780456651 @default.
• W2063399228 hasConcept C2781311116 @default.
• W2063399228 hasConcept C33288867 @default.
• W2063399228 hasConcept C502942594 @default.
• W2063399228 hasConcept C526805850 @default.
• W2063399228 hasConcept C54355233 @default.
• W2063399228 hasConcept C552990157 @default.
• W2063399228 hasConcept C55493867 @default.
• W2063399228 hasConcept C61320498 @default.
• W2063399228 hasConcept C62231903 @default.
• W2063399228 hasConcept C71924100 @default.
• W2063399228 hasConcept C86803240 @default.
• W2063399228 hasConcept C91965660 @default.
• W2063399228 hasConceptScore W2063399228C104317684 @default.
• W2063399228 hasConceptScore W2063399228C121608353 @default.
• W2063399228 hasConceptScore W2063399228C123321153 @default.
• W2063399228 hasConceptScore W2063399228C126322002 @default.
• W2063399228 hasConceptScore W2063399228C150194340 @default.
• W2063399228 hasConceptScore W2063399228C178790620 @default.
• W2063399228 hasConceptScore W2063399228C180754005 @default.
• W2063399228 hasConceptScore W2063399228C181199279 @default.
• W2063399228 hasConceptScore W2063399228C185592680 @default.
• W2063399228 hasConceptScore W2063399228C190727270 @default.
• W2063399228 hasConceptScore W2063399228C2778565081 @default.
• W2063399228 hasConceptScore W2063399228C2779767149 @default.
• W2063399228 hasConceptScore W2063399228C2780456651 @default.
• W2063399228 hasConceptScore W2063399228C2781311116 @default.
• W2063399228 hasConceptScore W2063399228C33288867 @default.
• W2063399228 hasConceptScore W2063399228C502942594 @default.
• W2063399228 hasConceptScore W2063399228C526805850 @default.
• W2063399228 hasConceptScore W2063399228C54355233 @default.
• W2063399228 hasConceptScore W2063399228C552990157 @default.
• W2063399228 hasConceptScore W2063399228C55493867 @default.
• W2063399228 hasConceptScore W2063399228C61320498 @default.
• W2063399228 hasConceptScore W2063399228C62231903 @default.
• W2063399228 hasConceptScore W2063399228C71924100 @default.
• W2063399228 hasConceptScore W2063399228C86803240 @default.
• W2063399228 hasConceptScore W2063399228C91965660 @default.
• W2063399228 hasIssue "1-2" @default.
• W2063399228 hasLocation W20633992281 @default.
• W2063399228 hasLocation W20633992282 @default.
• W2063399228 hasOpenAccess W2063399228 @default.
• W2063399228 hasPrimaryLocation W20633992281 @default.
• W2063399228 hasRelatedWork W1584164555 @default.
• W2063399228 hasRelatedWork W1993640737 @default.
• W2063399228 hasRelatedWork W2058002508 @default.

• next