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• W2063399248 abstract "We have reported the synthesis and biological evaluation of a decavanadate Na(4)Co(H(2)O)(6)V(10)O(28).18H(2)O (CoV(10)) designed as a potential antitumoral agent. The human cancer cell lines SMMC-7721 (liver cancer) and SK-OV-3 (ovary cancer) were tested for their viability by the MTT method in vitro, which showed that the compound exhibited a remarkable activity against two cell lines with IC(50) values smaller than 0.24 microg/mL, 0.32 microg/mL, respectively. CoV(10) showed the tumor growth suppression for Hep-A-22 (mice liver cancer) in tumor bearing mice in vivo. In addition, using flow cytometry analysis, the ratio of apoptotic cells was up to 8.33% with treatment of CoV(10) at 1.56 microg/mL after 30 min, suggesting that the antitumoral activity of CoV(10) comes from the activation of the apoptotic pathway." @default.
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• W2063399248 date "2009-01-01" @default.
• W2063399248 modified "2023-10-12" @default.
• W2063399248 title "Synthesis and biological evaluation of decavanadate Na4Co(H2O)6V10O28·18H2O" @default.
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• W2063399248 doi "https://doi.org/10.1016/j.biopha.2008.01.006" @default.
• W2063399248 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18378419" @default.
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