FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2063406011> ?p ?o ?g. }

• W2063406011 endingPage "111" @default.
• W2063406011 startingPage "105" @default.
• W2063406011 abstract "Dicentric chromosomes are observed in many malignant diseases including myelodysplasia (MDS) and acute myeloid leukemia (AML) and have often been observed in a subset of these diseases, namely therapy-related MDS (t-MDS) and AML (t-AML). Using fluorescence in situ hybridization (FISH) with centromere-specific probes, we investigated the frequency and type of dicentric chromosomes in 180 consecutive patients with t-MDS and t-AML and in 231 consecutive patients with de novo MDS and AML, whose karyotypes had been studied previously by conventional G-banding. Twenty-seven out of 180 patients with t-MDS or t-AML presented dicentric chromosomes compared to only seven out of 231 patients with de novo disease (P = 0.00003). A dic(1q;7p) was observed in 10 cases, a dic(5p;17q) was observed in six cases, whereas various isodicentric chromosomes were observed in six cases. Excluding these six cases with isodicentrics, all 25 patients with dicentric chromosomes had involvement of at least one of the chromosome arms 1q, 5p, or 7p resulting in monosomy for 5q or 7q, and/or trisomy for 1q. Patients with dicentric chromosomes presented significantly more often as t-MDS compared to patients without dicentrics (P = 0.046), and the presence of a dicentric chromosome was significantly related to previous therapy with alkylating agents (P = 0.026). Thus, only one out of 27 patients with a dicentric chromosome had not previously received an alkylating agent. A specific susceptibility to breakage at the centromere after exposure to alkylating agents is suggested and may explain the frequent loss of whole chromosomes, in particular chromosomes 5 and 7 in t-MDS and t-AML, if the breaks are not followed by rejoining. Leukemia (2000) 14, 105-111." @default.
• W2063406011 created "2016-06-24" @default.
• W2063406011 creator A5006055158 @default.
• W2063406011 creator A5056500582 @default.
• W2063406011 date "2000-01-01" @default.
• W2063406011 modified "2023-10-15" @default.
• W2063406011 title "Increased frequency of dicentric chromosomes in therapy-related MDS and AML compared to de novo disease is significantly related to previous treatment with alkylating agents and suggests a specific susceptibility to chromosome breakage at the centromere" @default.
• W2063406011 cites W1494138467 @default.
• W2063406011 cites W1495036323 @default.
• W2063406011 cites W1796305773 @default.
• W2063406011 cites W1829759922 @default.
• W2063406011 cites W1959063562 @default.
• W2063406011 cites W1978831300 @default.
• W2063406011 cites W1980725176 @default.
• W2063406011 cites W1996208795 @default.
• W2063406011 cites W2001018499 @default.
• W2063406011 cites W2004951223 @default.
• W2063406011 cites W2007532842 @default.
• W2063406011 cites W2015358926 @default.
• W2063406011 cites W2019482913 @default.
• W2063406011 cites W2031454576 @default.
• W2063406011 cites W2037735187 @default.
• W2063406011 cites W2048791678 @default.
• W2063406011 cites W2051139978 @default.
• W2063406011 cites W2053081382 @default.
• W2063406011 cites W2083912192 @default.
• W2063406011 cites W2151773081 @default.
• W2063406011 cites W2152196320 @default.
• W2063406011 cites W2287952 @default.
• W2063406011 cites W2288473528 @default.
• W2063406011 cites W2288605453 @default.
• W2063406011 cites W2316623792 @default.
• W2063406011 cites W2414842751 @default.
• W2063406011 cites W4251365833 @default.
• W2063406011 doi "https://doi.org/10.1038/sj.leu.2401594" @default.
• W2063406011 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10637484" @default.
• W2063406011 hasPublicationYear "2000" @default.
• W2063406011 type Work @default.
• W2063406011 sameAs 2063406011 @default.
• W2063406011 citedByCount "66" @default.
• W2063406011 countsByYear W20634060112012 @default.
• W2063406011 countsByYear W20634060112013 @default.
• W2063406011 countsByYear W20634060112014 @default.
• W2063406011 countsByYear W20634060112016 @default.
• W2063406011 countsByYear W20634060112017 @default.
• W2063406011 countsByYear W20634060112018 @default.
• W2063406011 countsByYear W20634060112019 @default.
• W2063406011 countsByYear W20634060112020 @default.
• W2063406011 countsByYear W20634060112021 @default.
• W2063406011 countsByYear W20634060112022 @default.
• W2063406011 countsByYear W20634060112023 @default.
• W2063406011 crossrefType "journal-article" @default.
• W2063406011 hasAuthorship W2063406011A5006055158 @default.
• W2063406011 hasAuthorship W2063406011A5056500582 @default.
• W2063406011 hasBestOaLocation W20634060111 @default.
• W2063406011 hasConcept C103037022 @default.
• W2063406011 hasConcept C104317684 @default.
• W2063406011 hasConcept C126322002 @default.
• W2063406011 hasConcept C174475383 @default.
• W2063406011 hasConcept C2776229224 @default.
• W2063406011 hasConcept C2777542201 @default.
• W2063406011 hasConcept C2779142324 @default.
• W2063406011 hasConcept C2779672484 @default.
• W2063406011 hasConcept C2780365373 @default.
• W2063406011 hasConcept C30481170 @default.
• W2063406011 hasConcept C53226629 @default.
• W2063406011 hasConcept C54355233 @default.
• W2063406011 hasConcept C63491729 @default.
• W2063406011 hasConcept C71924100 @default.
• W2063406011 hasConcept C86803240 @default.
• W2063406011 hasConceptScore W2063406011C103037022 @default.
• W2063406011 hasConceptScore W2063406011C104317684 @default.
• W2063406011 hasConceptScore W2063406011C126322002 @default.
• W2063406011 hasConceptScore W2063406011C174475383 @default.
• W2063406011 hasConceptScore W2063406011C2776229224 @default.
• W2063406011 hasConceptScore W2063406011C2777542201 @default.
• W2063406011 hasConceptScore W2063406011C2779142324 @default.
• W2063406011 hasConceptScore W2063406011C2779672484 @default.
• W2063406011 hasConceptScore W2063406011C2780365373 @default.
• W2063406011 hasConceptScore W2063406011C30481170 @default.
• W2063406011 hasConceptScore W2063406011C53226629 @default.
• W2063406011 hasConceptScore W2063406011C54355233 @default.
• W2063406011 hasConceptScore W2063406011C63491729 @default.
• W2063406011 hasConceptScore W2063406011C71924100 @default.
• W2063406011 hasConceptScore W2063406011C86803240 @default.
• W2063406011 hasIssue "1" @default.
• W2063406011 hasLocation W20634060111 @default.
• W2063406011 hasLocation W20634060112 @default.
• W2063406011 hasOpenAccess W2063406011 @default.
• W2063406011 hasPrimaryLocation W20634060111 @default.
• W2063406011 hasRelatedWork W109507493 @default.
• W2063406011 hasRelatedWork W1963497218 @default.
• W2063406011 hasRelatedWork W1974754966 @default.
• W2063406011 hasRelatedWork W1997246847 @default.
• W2063406011 hasRelatedWork W2029078006 @default.
• W2063406011 hasRelatedWork W2129324495 @default.
• W2063406011 hasRelatedWork W2144160254 @default.
• W2063406011 hasRelatedWork W2403715258 @default.

• next