FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2063409066> ?p ?o ?g. }

• W2063409066 endingPage "1116" @default.
• W2063409066 startingPage "1108" @default.
• W2063409066 abstract "The aim of the present study was to explore the effect of DJ-1-mediated PI3K/AKT/mTOR pathway on the proliferation, apoptosis, invasion, migration and other tumor biological characteristics of laryngeal squamous cell SNU-46, through stable transfection and overexpression of the DJ-1 gene. Retrovirus carrying DJ-1 gene was used to stabilize transfected human laryngeal squamous carcinoma SNU-46 cell line, and monoclonal cell line of stably overexpressed DJ-1 protein was screened out by G418. DJ-1 protein expression was determined by western blotting, and changes of p-AKT, p-mTOR and PTEN protein content were detected, followed by the detection of changes in proliferation, apoptosis, invasion, migration and other tumor biological characteristics of laryngeal squamous carcinoma cell line with stably transfected DJ-1 protein overexpression by flow cytometry, CCK-8 method and Transwell. We successfully constructed a laryngeal squamous carcinoma cell line of stably overexpressed DJ-1 protein and termed it SNU-46-DJ-1. After overexpression of DJ-1 protein, the levels of PTEN expression in laryngeal squamous cell SNU-46 decreased and p-AKT and p-mTOR protein expression levels increased. Compared to the untreated SNU-46 cells, the proliferation rate of SNU-46-DJ-1 cells increased (0.834±0.336 vs. 0.676±0.112; p<0.001); invasiveness was enhanced (165.7±13.6 vs. 100.0±17.4; p=0.001), the migration ability was enhanced (207.3±13.1 vs. 175.3±13.3; p=0.036), and the apoptosis rate decreased (3.533±5.167 vs. 16.397±5.447%; p=0.019). The overexpression of DJ-1 protein in laryngeal squamous carcinoma SNU-46 cells can accelerate proliferation rate, increase the invasion and migration capacity, and reduce apoptosis, by activating the PI3K/AKT/mTOR pathway." @default.
• W2063409066 created "2016-06-24" @default.
• W2063409066 creator A5003862415 @default.
• W2063409066 creator A5004296782 @default.
• W2063409066 creator A5014452125 @default.
• W2063409066 creator A5015204786 @default.
• W2063409066 creator A5024886981 @default.
• W2063409066 creator A5044883758 @default.
• W2063409066 creator A5045018467 @default.
• W2063409066 creator A5077362015 @default.
• W2063409066 date "2014-06-24" @default.
• W2063409066 modified "2023-09-30" @default.
• W2063409066 title "Effect of DJ-1 overexpression on the proliferation, apoptosis, invasion and migration of laryngeal squamous cell carcinoma SNU-46 cells through PI3K/AKT/mTOR" @default.
• W2063409066 cites W1967603366 @default.
• W2063409066 cites W1980364385 @default.
• W2063409066 cites W1985399632 @default.
• W2063409066 cites W1992321269 @default.
• W2063409066 cites W1995412458 @default.
• W2063409066 cites W1998704092 @default.
• W2063409066 cites W2009127180 @default.
• W2063409066 cites W2020830322 @default.
• W2063409066 cites W2029854095 @default.
• W2063409066 cites W2036005555 @default.
• W2063409066 cites W2036575905 @default.
• W2063409066 cites W2052853635 @default.
• W2063409066 cites W2067758224 @default.
• W2063409066 cites W2070766926 @default.
• W2063409066 cites W2072789843 @default.
• W2063409066 cites W2076317870 @default.
• W2063409066 cites W2078312014 @default.
• W2063409066 cites W2096560865 @default.
• W2063409066 cites W2103551853 @default.
• W2063409066 cites W2106258494 @default.
• W2063409066 cites W2118003229 @default.
• W2063409066 cites W2118621169 @default.
• W2063409066 cites W2120703739 @default.
• W2063409066 cites W2130792966 @default.
• W2063409066 cites W2138038992 @default.
• W2063409066 cites W2172200669 @default.
• W2063409066 doi "https://doi.org/10.3892/or.2014.3286" @default.
• W2063409066 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24969178" @default.
• W2063409066 hasPublicationYear "2014" @default.
• W2063409066 type Work @default.
• W2063409066 sameAs 2063409066 @default.
• W2063409066 citedByCount "22" @default.
• W2063409066 countsByYear W20634090662015 @default.
• W2063409066 countsByYear W20634090662016 @default.
• W2063409066 countsByYear W20634090662017 @default.
• W2063409066 countsByYear W20634090662018 @default.
• W2063409066 countsByYear W20634090662019 @default.
• W2063409066 countsByYear W20634090662020 @default.
• W2063409066 countsByYear W20634090662021 @default.
• W2063409066 countsByYear W20634090662022 @default.
• W2063409066 countsByYear W20634090662023 @default.
• W2063409066 crossrefType "journal-article" @default.
• W2063409066 hasAuthorship W2063409066A5003862415 @default.
• W2063409066 hasAuthorship W2063409066A5004296782 @default.
• W2063409066 hasAuthorship W2063409066A5014452125 @default.
• W2063409066 hasAuthorship W2063409066A5015204786 @default.
• W2063409066 hasAuthorship W2063409066A5024886981 @default.
• W2063409066 hasAuthorship W2063409066A5044883758 @default.
• W2063409066 hasAuthorship W2063409066A5045018467 @default.
• W2063409066 hasAuthorship W2063409066A5077362015 @default.
• W2063409066 hasBestOaLocation W20634090661 @default.
• W2063409066 hasConcept C1491633281 @default.
• W2063409066 hasConcept C153911025 @default.
• W2063409066 hasConcept C190283241 @default.
• W2063409066 hasConcept C2777609662 @default.
• W2063409066 hasConcept C2781018059 @default.
• W2063409066 hasConcept C29537977 @default.
• W2063409066 hasConcept C502942594 @default.
• W2063409066 hasConcept C54009773 @default.
• W2063409066 hasConcept C54355233 @default.
• W2063409066 hasConcept C553184892 @default.
• W2063409066 hasConcept C55493867 @default.
• W2063409066 hasConcept C62112901 @default.
• W2063409066 hasConcept C75217442 @default.
• W2063409066 hasConcept C81885089 @default.
• W2063409066 hasConcept C86554907 @default.
• W2063409066 hasConcept C86803240 @default.
• W2063409066 hasConceptScore W2063409066C1491633281 @default.
• W2063409066 hasConceptScore W2063409066C153911025 @default.
• W2063409066 hasConceptScore W2063409066C190283241 @default.
• W2063409066 hasConceptScore W2063409066C2777609662 @default.
• W2063409066 hasConceptScore W2063409066C2781018059 @default.
• W2063409066 hasConceptScore W2063409066C29537977 @default.
• W2063409066 hasConceptScore W2063409066C502942594 @default.
• W2063409066 hasConceptScore W2063409066C54009773 @default.
• W2063409066 hasConceptScore W2063409066C54355233 @default.
• W2063409066 hasConceptScore W2063409066C553184892 @default.
• W2063409066 hasConceptScore W2063409066C55493867 @default.
• W2063409066 hasConceptScore W2063409066C62112901 @default.
• W2063409066 hasConceptScore W2063409066C75217442 @default.
• W2063409066 hasConceptScore W2063409066C81885089 @default.
• W2063409066 hasConceptScore W2063409066C86554907 @default.
• W2063409066 hasConceptScore W2063409066C86803240 @default.
• W2063409066 hasIssue "3" @default.
• W2063409066 hasLocation W20634090661 @default.

• next