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• W2063427936 abstract "The liver is a privileged organ and has a lower incidence of rejection than other organs. However, immunosuppressive regimens are still required to control the alloreactive T-lymphocyte response after transplantation. These treatments may lead to severe complications, such as infectious diseases, cancers, cardiovascular diseases and chronic renal insufficiency. In clinical transplantation there is increasing evidence that some liver transplant recipients who cease taking immunosuppressive (IS) drugs maintain allograft function, suggesting that tolerance is already present. This strategy is feasible in 25-33% of liver transplant recipients. A series of experimental and clinical observations indicates that liver allografts can even provide tolerogenic properties for other organ grafts. In the clinical setting, clinical operational tolerance (COT) is defined as the absence of acute and chronic rejection and graft survival with normal function and histology in an IS-free, fully immunocompetent host, usually as an end result of a successful attempt at IS withdrawal. The exact mechanisms involved in achieving transplant tolerance remain unknown, although animal models suggest a possible role for regulatory T cells (Treg). Recent data have demonstrated an increase in the frequency of CD4+ CD25(high) T cells and FoxP3 transcripts during IS withdrawal in operationally tolerant liver transplant recipients. The data obtained from transcriptional profiling of the peripheral blood of IS-free liver transplant recipients suggest that there is a molecular signature of tolerance that could be employed to identify tolerant liver transplant recipients and that innate immune cells are likely to play a major role in the maintenance of COT after liver transplantation." @default.
• W2063427936 created "2016-06-24" @default.
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• W2063427936 date "2011-03-01" @default.
• W2063427936 modified "2023-10-03" @default.
• W2063427936 title "Desarrollo de inmunotolerancia en el trasplante hepático" @default.
• W2063427936 cites W1561829995 @default.
• W2063427936 cites W1813961098 @default.
• W2063427936 cites W1924680600 @default.
• W2063427936 cites W1963574332 @default.
• W2063427936 cites W1966773892 @default.
• W2063427936 cites W1966957841 @default.
• W2063427936 cites W1967702267 @default.
• W2063427936 cites W1972669750 @default.
• W2063427936 cites W1972955137 @default.
• W2063427936 cites W1973323884 @default.
• W2063427936 cites W1975667891 @default.
• W2063427936 cites W1976729044 @default.
• W2063427936 cites W1981631137 @default.
• W2063427936 cites W1982119903 @default.
• W2063427936 cites W1982636859 @default.
• W2063427936 cites W1988776224 @default.
• W2063427936 cites W1988850237 @default.
• W2063427936 cites W1993669291 @default.
• W2063427936 cites W1994334769 @default.
• W2063427936 cites W1996627587 @default.
• W2063427936 cites W1999832455 @default.
• W2063427936 cites W2000809311 @default.
• W2063427936 cites W2002726823 @default.
• W2063427936 cites W2005795026 @default.
• W2063427936 cites W2006075845 @default.
• W2063427936 cites W2006549902 @default.
• W2063427936 cites W2009034832 @default.
• W2063427936 cites W2012461482 @default.
• W2063427936 cites W2013013791 @default.
• W2063427936 cites W2018207594 @default.
• W2063427936 cites W2020672759 @default.
• W2063427936 cites W2022174161 @default.
• W2063427936 cites W2024351056 @default.
• W2063427936 cites W2025446247 @default.
• W2063427936 cites W2026637830 @default.
• W2063427936 cites W2026647673 @default.
• W2063427936 cites W2032627010 @default.
• W2063427936 cites W2032678054 @default.
• W2063427936 cites W2039801541 @default.
• W2063427936 cites W2040775375 @default.
• W2063427936 cites W2048070434 @default.
• W2063427936 cites W2048143404 @default.
• W2063427936 cites W2051896769 @default.
• W2063427936 cites W2054334209 @default.
• W2063427936 cites W2058311698 @default.
• W2063427936 cites W2061818211 @default.
• W2063427936 cites W2063820155 @default.
• W2063427936 cites W2075902442 @default.
• W2063427936 cites W2076208870 @default.
• W2063427936 cites W2076978205 @default.
• W2063427936 cites W2077597327 @default.
• W2063427936 cites W2085315494 @default.
• W2063427936 cites W2087967190 @default.
• W2063427936 cites W2088021543 @default.
• W2063427936 cites W2088942316 @default.
• W2063427936 cites W2090478375 @default.
• W2063427936 cites W2091489376 @default.
• W2063427936 cites W2091729451 @default.
• W2063427936 cites W2094490544 @default.
• W2063427936 cites W2100215924 @default.
• W2063427936 cites W2101435342 @default.
• W2063427936 cites W2104959557 @default.
• W2063427936 cites W2107113286 @default.
• W2063427936 cites W2118471749 @default.
• W2063427936 cites W2122445377 @default.
• W2063427936 cites W2122801528 @default.
• W2063427936 cites W2123987776 @default.
• W2063427936 cites W2124060773 @default.
• W2063427936 cites W2131735132 @default.
• W2063427936 cites W2138961639 @default.
• W2063427936 cites W2141113674 @default.
• W2063427936 cites W2153266679 @default.
• W2063427936 cites W2154271397 @default.
• W2063427936 cites W2154455036 @default.
• W2063427936 cites W2161929236 @default.
• W2063427936 cites W2167926698 @default.
• W2063427936 cites W2330550147 @default.
• W2063427936 cites W4235550928 @default.
• W2063427936 cites W4248168278 @default.
• W2063427936 cites W4294349031 @default.
• W2063427936 cites W4313324526 @default.
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• W2063427936 doi "https://doi.org/10.1016/j.gastrohep.2010.11.007" @default.
• W2063427936 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21376423" @default.
• W2063427936 hasPublicationYear "2011" @default.
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