FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2063432246> ?p ?o ?g. }

• W2063432246 endingPage "1552" @default.
• W2063432246 startingPage "1547" @default.
• W2063432246 abstract "Endotoxin is thought to contribute to pulmonary hyperresponsiveness in byssinosis, asthma, and the acute respiratory distress syndrome (ARDS). The aim of this study was to elucidate the mechanism of this phenomenon in the isolated, blood-free perfused mouse lung. Perfusion with lipopolysaccharide (LPS) had no effect on pulmonary resistance or pulmonary artery pressure, but induced airway hyperreactivity (AHR) to methacholine (MCh) and pulmonary vascular hyperreactivity (VHR) to platelet-activating factor (PAF). Blockade of the thromboxane/endoperoxide (TP) receptor with SQ29.548 completely protected against LPS-induced AHR and VHR. Blockade of cyclooxygenase-2 (COX-2) abolished LPS-induced VHR but suppressed LPS-induced AHR only marginally. COX-2 messenger RNA was upregulated in LPS-treated lungs, and inhibition of transcription with actinomycin D or of protein biosynthesis with cycloheximide protected against LPS-induced VHR but not AHR. Pretreatment with the radical scavenger N-acetylcysteine partly protected against LPS-induced AHR. In addition, perfusion of mouse lungs with the isoprostane 8-epiprostaglandin F(2alpha) (8-epi-PGF(2alpha)), which may be formed as a consequence of oxidative stress in the lung, elicited AHR, which was completely blocked by SQ29.548. Enzyme immunoassay did not detect either 8-epi-PGF(2alpha )or thromboxane B(2) in perfusate samples. Our findings show that LPS induces AHR and VHR in mouse lungs via activation of the TP receptor. Although induction of VHR depends on COX-2 activity, AHR is largely mediated by a non-COX-derived TP agonist, which might be a product of radical-induced lipid peroxidation." @default.
• W2063432246 created "2016-06-24" @default.
• W2063432246 creator A5043548617 @default.
• W2063432246 creator A5060284965 @default.
• W2063432246 date "2000-10-01" @default.
• W2063432246 modified "2023-10-15" @default.
• W2063432246 title "Mechanisms of Endotoxin-Induced Airway and Pulmonary Vascular Hyperreactivity in Mice" @default.
• W2063432246 cites W1526590732 @default.
• W2063432246 cites W1543776771 @default.
• W2063432246 cites W1882996705 @default.
• W2063432246 cites W1972153352 @default.
• W2063432246 cites W1985660074 @default.
• W2063432246 cites W1999917169 @default.
• W2063432246 cites W2004104598 @default.
• W2063432246 cites W2005935182 @default.
• W2063432246 cites W2013394968 @default.
• W2063432246 cites W2026340205 @default.
• W2063432246 cites W2042306961 @default.
• W2063432246 cites W2047117412 @default.
• W2063432246 cites W2049291013 @default.
• W2063432246 cites W2055553130 @default.
• W2063432246 cites W2065534461 @default.
• W2063432246 cites W2067473360 @default.
• W2063432246 cites W2070479807 @default.
• W2063432246 cites W2072097525 @default.
• W2063432246 cites W2073068176 @default.
• W2063432246 cites W2078740535 @default.
• W2063432246 cites W2084147958 @default.
• W2063432246 cites W2088302531 @default.
• W2063432246 cites W2093297006 @default.
• W2063432246 cites W2093585097 @default.
• W2063432246 cites W2106645827 @default.
• W2063432246 cites W2148080069 @default.
• W2063432246 cites W2172002311 @default.
• W2063432246 cites W2177322348 @default.
• W2063432246 cites W2292450456 @default.
• W2063432246 cites W2317320087 @default.
• W2063432246 cites W2395030214 @default.
• W2063432246 cites W2474176322 @default.
• W2063432246 doi "https://doi.org/10.1164/ajrccm.162.4.9912079" @default.
• W2063432246 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11029375" @default.
• W2063432246 hasPublicationYear "2000" @default.
• W2063432246 type Work @default.
• W2063432246 sameAs 2063432246 @default.
• W2063432246 citedByCount "77" @default.
• W2063432246 countsByYear W20634322462012 @default.
• W2063432246 countsByYear W20634322462013 @default.
• W2063432246 countsByYear W20634322462015 @default.
• W2063432246 countsByYear W20634322462016 @default.
• W2063432246 countsByYear W20634322462019 @default.
• W2063432246 countsByYear W20634322462020 @default.
• W2063432246 countsByYear W20634322462021 @default.
• W2063432246 crossrefType "journal-article" @default.
• W2063432246 hasAuthorship W2063432246A5043548617 @default.
• W2063432246 hasAuthorship W2063432246A5060284965 @default.
• W2063432246 hasBestOaLocation W20634322462 @default.
• W2063432246 hasConcept C126322002 @default.
• W2063432246 hasConcept C134018914 @default.
• W2063432246 hasConcept C170493617 @default.
• W2063432246 hasConcept C181199279 @default.
• W2063432246 hasConcept C185592680 @default.
• W2063432246 hasConcept C203014093 @default.
• W2063432246 hasConcept C2776151105 @default.
• W2063432246 hasConcept C2776785769 @default.
• W2063432246 hasConcept C2777714996 @default.
• W2063432246 hasConcept C2778754761 @default.
• W2063432246 hasConcept C2779689624 @default.
• W2063432246 hasConcept C2780829032 @default.
• W2063432246 hasConcept C2781024287 @default.
• W2063432246 hasConcept C55493867 @default.
• W2063432246 hasConcept C71924100 @default.
• W2063432246 hasConcept C89560881 @default.
• W2063432246 hasConcept C98274493 @default.
• W2063432246 hasConceptScore W2063432246C126322002 @default.
• W2063432246 hasConceptScore W2063432246C134018914 @default.
• W2063432246 hasConceptScore W2063432246C170493617 @default.
• W2063432246 hasConceptScore W2063432246C181199279 @default.
• W2063432246 hasConceptScore W2063432246C185592680 @default.
• W2063432246 hasConceptScore W2063432246C203014093 @default.
• W2063432246 hasConceptScore W2063432246C2776151105 @default.
• W2063432246 hasConceptScore W2063432246C2776785769 @default.
• W2063432246 hasConceptScore W2063432246C2777714996 @default.
• W2063432246 hasConceptScore W2063432246C2778754761 @default.
• W2063432246 hasConceptScore W2063432246C2779689624 @default.
• W2063432246 hasConceptScore W2063432246C2780829032 @default.
• W2063432246 hasConceptScore W2063432246C2781024287 @default.
• W2063432246 hasConceptScore W2063432246C55493867 @default.
• W2063432246 hasConceptScore W2063432246C71924100 @default.
• W2063432246 hasConceptScore W2063432246C89560881 @default.
• W2063432246 hasConceptScore W2063432246C98274493 @default.
• W2063432246 hasIssue "4" @default.
• W2063432246 hasLocation W20634322461 @default.
• W2063432246 hasLocation W20634322462 @default.
• W2063432246 hasLocation W20634322463 @default.
• W2063432246 hasOpenAccess W2063432246 @default.
• W2063432246 hasPrimaryLocation W20634322461 @default.
• W2063432246 hasRelatedWork W1998530272 @default.
• W2063432246 hasRelatedWork W2010417523 @default.

• next