FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2063440165> ?p ?o ?g. }

• W2063440165 endingPage "e74" @default.
• W2063440165 startingPage "e74" @default.
• W2063440165 abstract "Individuals with obesity and type 2 diabetes (T2D) are typically insulin resistant, exhibiting impaired skeletal muscle glucose uptake. Animal and cell culture experiments have shown that site-specific phosphorylation of the Rab-GTPase-activating proteins AS160 and TBC1D1 is critical for GLUT4 translocation facilitating glucose uptake, but their regulation in human skeletal muscle is not well understood.Here, lean, obese and T2D subjects underwent a euglycemic-hyperinsulinemic clamp, and vastus lateralis muscle biopsies were obtained before, and at 30 and 180 min post insulin infusion.Obese and T2D subjects had higher body mass indexes and fasting insulin concentrations, and T2D subjects showed insulin resistance. Consistent with the clamp findings, T2D subjects had impaired insulin-stimulated phosphorylation of AS160 Thr(642), a site previously shown to be important in glucose uptake in rodents. Interestingly, insulin-stimulated phosphorylation of TBC1D1 Thr(590), a site shown to be regulated by insulin in rodents, was only increased in T2D subjects, although the functional significance of this difference is unknown.These data show that insulin differentially regulates AS160 and TBC1D1 phosphorylation in human skeletal muscle. Impaired insulin-stimulated glucose uptake in T2D subjects is accompanied by dysregulation of AS160 and TBC1D1 phosphorylation in skeletal muscle, suggesting that these proteins may regulate glucose uptake in humans." @default.
• W2063440165 created "2016-06-24" @default.
• W2063440165 creator A5001871630 @default.
• W2063440165 creator A5015635878 @default.
• W2063440165 creator A5020890107 @default.
• W2063440165 creator A5029750430 @default.
• W2063440165 creator A5034471398 @default.
• W2063440165 creator A5039947894 @default.
• W2063440165 creator A5059051276 @default.
• W2063440165 creator A5061656649 @default.
• W2063440165 date "2013-06-10" @default.
• W2063440165 modified "2023-10-16" @default.
• W2063440165 title "Insulin stimulation regulates AS160 and TBC1D1 phosphorylation sites in human skeletal muscle" @default.
• W2063440165 cites W1963479552 @default.
• W2063440165 cites W2000198788 @default.
• W2063440165 cites W2010763118 @default.
• W2063440165 cites W2011094582 @default.
• W2063440165 cites W2017414380 @default.
• W2063440165 cites W2058860541 @default.
• W2063440165 cites W2063958537 @default.
• W2063440165 cites W2098974443 @default.
• W2063440165 cites W2101118920 @default.
• W2063440165 cites W2101715194 @default.
• W2063440165 cites W2102166276 @default.
• W2063440165 cites W2110219586 @default.
• W2063440165 cites W2116024321 @default.
• W2063440165 cites W2133795831 @default.
• W2063440165 cites W2147249344 @default.
• W2063440165 cites W2148321229 @default.
• W2063440165 cites W2152840919 @default.
• W2063440165 cites W2167698452 @default.
• W2063440165 cites W2169358395 @default.
• W2063440165 cites W2170864435 @default.
• W2063440165 doi "https://doi.org/10.1038/nutd.2013.13" @default.
• W2063440165 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3697402" @default.
• W2063440165 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23752133" @default.
• W2063440165 hasPublicationYear "2013" @default.
• W2063440165 type Work @default.
• W2063440165 sameAs 2063440165 @default.
• W2063440165 citedByCount "35" @default.
• W2063440165 countsByYear W20634401652014 @default.
• W2063440165 countsByYear W20634401652015 @default.
• W2063440165 countsByYear W20634401652016 @default.
• W2063440165 countsByYear W20634401652017 @default.
• W2063440165 countsByYear W20634401652018 @default.
• W2063440165 countsByYear W20634401652019 @default.
• W2063440165 countsByYear W20634401652020 @default.
• W2063440165 countsByYear W20634401652021 @default.
• W2063440165 countsByYear W20634401652022 @default.
• W2063440165 countsByYear W20634401652023 @default.
• W2063440165 crossrefType "journal-article" @default.
• W2063440165 hasAuthorship W2063440165A5001871630 @default.
• W2063440165 hasAuthorship W2063440165A5015635878 @default.
• W2063440165 hasAuthorship W2063440165A5020890107 @default.
• W2063440165 hasAuthorship W2063440165A5029750430 @default.
• W2063440165 hasAuthorship W2063440165A5034471398 @default.
• W2063440165 hasAuthorship W2063440165A5039947894 @default.
• W2063440165 hasAuthorship W2063440165A5059051276 @default.
• W2063440165 hasAuthorship W2063440165A5061656649 @default.
• W2063440165 hasBestOaLocation W20634401651 @default.
• W2063440165 hasConcept C112446052 @default.
• W2063440165 hasConcept C11960822 @default.
• W2063440165 hasConcept C126322002 @default.
• W2063440165 hasConcept C134018914 @default.
• W2063440165 hasConcept C161573976 @default.
• W2063440165 hasConcept C2776188179 @default.
• W2063440165 hasConcept C2777180221 @default.
• W2063440165 hasConcept C2777391703 @default.
• W2063440165 hasConcept C2777866211 @default.
• W2063440165 hasConcept C2778808658 @default.
• W2063440165 hasConcept C2779306644 @default.
• W2063440165 hasConcept C2779959927 @default.
• W2063440165 hasConcept C2780352109 @default.
• W2063440165 hasConcept C555293320 @default.
• W2063440165 hasConcept C71924100 @default.
• W2063440165 hasConcept C86803240 @default.
• W2063440165 hasConcept C95444343 @default.
• W2063440165 hasConceptScore W2063440165C112446052 @default.
• W2063440165 hasConceptScore W2063440165C11960822 @default.
• W2063440165 hasConceptScore W2063440165C126322002 @default.
• W2063440165 hasConceptScore W2063440165C134018914 @default.
• W2063440165 hasConceptScore W2063440165C161573976 @default.
• W2063440165 hasConceptScore W2063440165C2776188179 @default.
• W2063440165 hasConceptScore W2063440165C2777180221 @default.
• W2063440165 hasConceptScore W2063440165C2777391703 @default.
• W2063440165 hasConceptScore W2063440165C2777866211 @default.
• W2063440165 hasConceptScore W2063440165C2778808658 @default.
• W2063440165 hasConceptScore W2063440165C2779306644 @default.
• W2063440165 hasConceptScore W2063440165C2779959927 @default.
• W2063440165 hasConceptScore W2063440165C2780352109 @default.
• W2063440165 hasConceptScore W2063440165C555293320 @default.
• W2063440165 hasConceptScore W2063440165C71924100 @default.
• W2063440165 hasConceptScore W2063440165C86803240 @default.
• W2063440165 hasConceptScore W2063440165C95444343 @default.
• W2063440165 hasIssue "6" @default.
• W2063440165 hasLocation W20634401651 @default.
• W2063440165 hasLocation W20634401652 @default.
• W2063440165 hasLocation W20634401653 @default.

• next