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• W2063444857 abstract "In order to assess the utility of margin width in relation to other histopathologic features as a determinant of local control in ductal carcinoma in situ (DCIS) of the breast, we retrospectively examined the treatment of 109 breasts treated with (n = 54) or without adjuvant radiotherapy (n = 55). Median follow-up was 49 and 54 months for patients treated with excision alone (E) or excision plus adjuvant radiotherapy (E+XRT), respectively. Cases treated with E+XRT were significantly larger and had a trend towards closer surgical margins than those treated with E alone. For all cases, margin width < or = 1 mm and lesion diameter >15 mm were significantly associated with increased local recurrence. Lesion size < or = 15 mm was associated with no cases of local failure regardless of treatment arm. For lesions >15 mm in diameter, there was a significant decrease in 5-year local failure with E+XRT compared to E alone (21% vs. 36%, P = 0.03). Tumor margin >1 mm was associated with a low rate of 5-year local failure for either E alone or E+XRT (10.9% vs. 4.6%, P = NS). Tumor margin < = 1 mm had a high rate of local failure that was not significantly decreased by the addition of adjuvant radiotherapy. These results show that large diameter (>15 mm) and close surgical margins (< or = 1 mm) are the dominant risk factors for local recurrence in DCIS. E+XRT significantly decreased local failure risk compared to E alone for large lesions but not for those with close margins." @default.
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• W2063444857 date "2001-01-01" @default.
• W2063444857 modified "2023-10-05" @default.
• W2063444857 title "Margin width as a determinant of local control with and without radiation therapy for ductal carcinoma in situ (DCIS) of the breast" @default.
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• W2063444857 doi "https://doi.org/10.1002/ijc.10357" @default.
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