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• W2063451381 abstract "The effects of genistein on neovascularization, vascular endothelial growth factor (VEGF), and hypoxia inducible factor 1α (HIF1α) protein expression in a mouse model of oxygen-induced retinopathy were studied. The model of oxygen-induced retinal neovascularization was induced in newborn C57BL/6 mice by exposing 7-day-old mice to 75% oxygen for 5 days and then housing them in room air (relative hypoxia). Retinopathy was assessed by quantitation of vascular cell nuclei anterior to inner limiting membrane. Judged by relative fluorescence using a confocal scanning laser microscope coupled to a computer, VEGF and HIF1α protein expression were investigated. Genistein markedly inhibited the numbers of nuclei protruding above the inner limiting membrane under relative hypoxia conditions. The levels of nuclei numbers were suppressed by 50, 100, and 200 mg/kg body weight /day genistein to 87.4%, 72.0%, and 59.4%, respectively, compared to that untreated with genistein. VEGF protein was constitutively expressed in the preretinal area under normoxia conditions. Genistein markedly inhibited relative-hypoxia-elicited VEGF expression elevation in a dose-dependent manner. HIF1α expression was also observed in normoxia conditions. There was a 2.4-fold induction in preretinal HIF1α expression in oxygen-reared animals when compared to room-air–reared animals. Genistein dose-dependently suppressed HIF1α protein expression. These results indicated that the inhibition of VEGF and HIF1α protein expression by genistein may partly account for its effect on retinal neovascularization in vivo, and genistein could be an effective agent in the prevention and treatment of ocular neovascularization." @default.
• W2063451381 created "2016-06-24" @default.
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• W2063451381 date "2005-04-01" @default.
• W2063451381 modified "2023-10-15" @default.
• W2063451381 title "Genistein Inhibited Retinal Neovascularization and Expression of Vascular Endothelial Growth Factor and Hypoxia Inducible Factor 1α in a Mouse Model of Oxygen-Induced Retinopathy" @default.
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• W2063451381 doi "https://doi.org/10.1089/jop.2005.21.107" @default.
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