FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2063456927> ?p ?o ?g. }

• W2063456927 endingPage "97" @default.
• W2063456927 startingPage "91" @default.
• W2063456927 abstract "Cellular p53 and its downstream mediator p21, the major cellular growth suppression and DNA repair markers, have recently been implicated in viral amplification. Here, we show that herpes simplex virus type 2 (HSV-2) infection of both HCT116 p53(+/+)and NIH3T3 cells resulted in sustained increases of p21. HSV-2 infection did not increase cellular p53 expression, but led to phosphorylation of this protein at Ser20. This phosphorylation was accompanied by the increase of p21 protein levels. Furthermore, specific knockdown of endogenous p21 by siRNAs severely impaired virus production represented by HSV envelope glycoprotein B (gB) expression and progeny virus titers. Disruption of the p53-p21 pathway by either knocking down p53 in HCT116 p53(+/+) and NIH3T3 cells or using p53-deficient HCT116 p53(-/-) cells, led to a significant reduction of HSV-2 production. Together, these results suggest that the p53-p21 pathway is required for efficient HSV-2 lytic replication cycle. Because HSV infection induces the G0/G1 phase arrest at the early step of lytic-replication cycle, we propose that HSV-2 might hijack the cellular p53-p21 pathway to arrest the host cell cycle at G0/G1 phase, blocking cellular DNA synthesis, for its own benefit, i.e., to favor its own viral replication by avoiding competition in generating viral nucleotide pools." @default.
• W2063456927 created "2016-06-24" @default.
• W2063456927 creator A5010386617 @default.
• W2063456927 creator A5015686835 @default.
• W2063456927 creator A5040206124 @default.
• W2063456927 creator A5049341927 @default.
• W2063456927 creator A5058484759 @default.
• W2063456927 creator A5067316446 @default.
• W2063456927 date "2012-10-01" @default.
• W2063456927 modified "2023-09-24" @default.
• W2063456927 title "Disruption of the p53–p21 pathway inhibits efficiency of the lytic-replication cycle of herpes simplex virus type 2 (HSV-2)" @default.
• W2063456927 cites W1555996845 @default.
• W2063456927 cites W1621865896 @default.
• W2063456927 cites W1937607074 @default.
• W2063456927 cites W1968191203 @default.
• W2063456927 cites W1969680550 @default.
• W2063456927 cites W1970278963 @default.
• W2063456927 cites W1991494214 @default.
• W2063456927 cites W1996532455 @default.
• W2063456927 cites W2001955335 @default.
• W2063456927 cites W2022431825 @default.
• W2063456927 cites W2023555403 @default.
• W2063456927 cites W2023703530 @default.
• W2063456927 cites W2031688775 @default.
• W2063456927 cites W2055011486 @default.
• W2063456927 cites W2064515581 @default.
• W2063456927 cites W2064790766 @default.
• W2063456927 cites W2066278365 @default.
• W2063456927 cites W2072088194 @default.
• W2063456927 cites W2077138884 @default.
• W2063456927 cites W2079706088 @default.
• W2063456927 cites W2080961798 @default.
• W2063456927 cites W2083042409 @default.
• W2063456927 cites W2087379913 @default.
• W2063456927 cites W2092235329 @default.
• W2063456927 cites W2097951637 @default.
• W2063456927 cites W2098207727 @default.
• W2063456927 cites W2098308748 @default.
• W2063456927 cites W2102297492 @default.
• W2063456927 cites W2102740981 @default.
• W2063456927 cites W2106633782 @default.
• W2063456927 cites W2118578616 @default.
• W2063456927 cites W2118713752 @default.
• W2063456927 cites W2122073994 @default.
• W2063456927 cites W2125831899 @default.
• W2063456927 cites W2131928677 @default.
• W2063456927 cites W2135735391 @default.
• W2063456927 cites W2137162246 @default.
• W2063456927 cites W2138657695 @default.
• W2063456927 cites W2140320694 @default.
• W2063456927 cites W2143197026 @default.
• W2063456927 cites W2149439920 @default.
• W2063456927 cites W2156244991 @default.
• W2063456927 cites W2161105855 @default.
• W2063456927 cites W2162262059 @default.
• W2063456927 cites W2168790441 @default.
• W2063456927 cites W2169336597 @default.
• W2063456927 cites W2170800093 @default.
• W2063456927 cites W2181565914 @default.
• W2063456927 cites W2332582619 @default.
• W2063456927 doi "https://doi.org/10.1016/j.virusres.2012.07.011" @default.
• W2063456927 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22820403" @default.
• W2063456927 hasPublicationYear "2012" @default.
• W2063456927 type Work @default.
• W2063456927 sameAs 2063456927 @default.
• W2063456927 citedByCount "3" @default.
• W2063456927 countsByYear W20634569272013 @default.
• W2063456927 countsByYear W20634569272016 @default.
• W2063456927 countsByYear W20634569272019 @default.
• W2063456927 crossrefType "journal-article" @default.
• W2063456927 hasAuthorship W2063456927A5010386617 @default.
• W2063456927 hasAuthorship W2063456927A5015686835 @default.
• W2063456927 hasAuthorship W2063456927A5040206124 @default.
• W2063456927 hasAuthorship W2063456927A5049341927 @default.
• W2063456927 hasAuthorship W2063456927A5058484759 @default.
• W2063456927 hasAuthorship W2063456927A5067316446 @default.
• W2063456927 hasConcept C105696609 @default.
• W2063456927 hasConcept C140704245 @default.
• W2063456927 hasConcept C1491633281 @default.
• W2063456927 hasConcept C159047783 @default.
• W2063456927 hasConcept C182615771 @default.
• W2063456927 hasConcept C2522874641 @default.
• W2063456927 hasConcept C2781196997 @default.
• W2063456927 hasConcept C29537977 @default.
• W2063456927 hasConcept C54355233 @default.
• W2063456927 hasConcept C552990157 @default.
• W2063456927 hasConcept C73573662 @default.
• W2063456927 hasConcept C86803240 @default.
• W2063456927 hasConcept C95444343 @default.
• W2063456927 hasConceptScore W2063456927C105696609 @default.
• W2063456927 hasConceptScore W2063456927C140704245 @default.
• W2063456927 hasConceptScore W2063456927C1491633281 @default.
• W2063456927 hasConceptScore W2063456927C159047783 @default.
• W2063456927 hasConceptScore W2063456927C182615771 @default.
• W2063456927 hasConceptScore W2063456927C2522874641 @default.
• W2063456927 hasConceptScore W2063456927C2781196997 @default.
• W2063456927 hasConceptScore W2063456927C29537977 @default.
• W2063456927 hasConceptScore W2063456927C54355233 @default.

• next