Matches in SemOpenAlex for { <https://semopenalex.org/work/W2063467319> ?p ?o ?g. }
- W2063467319 endingPage "125" @default.
- W2063467319 startingPage "107" @default.
- W2063467319 abstract "Platelet-activating factor and somatostatin receptors, two G protein-coupled receptors expressed in the rat hippocampus, were analyzed for the downstream signaling pathways in Chinese hamster ovary cells stably expressing each receptor. Ligand stimulation to each CHO cell line induced (1) inhibition of forskolin-induced accumulation of cAMP, (2) arachidonate release, and (3) activation of mitogen-activated protein kinase and MAP kinase kinase. In contrast, inositol phosphate breakdown was seen only in the PAF-stimulated CHO cells. The induction of these signals accompanied no detectable Ras activation. Suppression of the signals by pertussis toxin was almost complete for the somatostatin receptor but partial for the PAF receptor, suggesting that the somatostatin receptor couples only with PTX-sensitive G protein, while the PAF receptor couples with both PTX-sensitive and -insensitive G proteins. A model of G protein-mediated signaling pathways was proposed in which the signals from Gi and those from Gq converge at MAP kinase kinase and lead to arachidonate release. The present system using CHO cells is useful for analyzing signaling pathways from G proteins to MAP kinase kinase and will thereby provide clues for understanding the mechanisms underlying the physiological and pathological events mediated by PAF, somatostatin, and other G protein-coupled receptors in the central nervous system and other tissues." @default.
- W2063467319 created "2016-06-24" @default.
- W2063467319 creator A5008934626 @default.
- W2063467319 creator A5024316557 @default.
- W2063467319 creator A5026264338 @default.
- W2063467319 creator A5040380388 @default.
- W2063467319 creator A5043589064 @default.
- W2063467319 creator A5058080620 @default.
- W2063467319 creator A5074514600 @default.
- W2063467319 date "1994-11-01" @default.
- W2063467319 modified "2023-10-03" @default.
- W2063467319 title "Activation of Mitogen-Activated Protein Kinase and Arachidonate Release via Two G Protein-Coupled Receptors Expressed in the Rat Hippocampus" @default.
- W2063467319 cites W1480719130 @default.
- W2063467319 cites W1496431312 @default.
- W2063467319 cites W1511459507 @default.
- W2063467319 cites W1523969239 @default.
- W2063467319 cites W1525671373 @default.
- W2063467319 cites W1526528713 @default.
- W2063467319 cites W1531194664 @default.
- W2063467319 cites W1533895575 @default.
- W2063467319 cites W1544352682 @default.
- W2063467319 cites W1546944401 @default.
- W2063467319 cites W1551079196 @default.
- W2063467319 cites W1558848958 @default.
- W2063467319 cites W1563821664 @default.
- W2063467319 cites W1566442216 @default.
- W2063467319 cites W1570643773 @default.
- W2063467319 cites W1573821584 @default.
- W2063467319 cites W1581952739 @default.
- W2063467319 cites W1583525962 @default.
- W2063467319 cites W1590871522 @default.
- W2063467319 cites W1606588479 @default.
- W2063467319 cites W1608649721 @default.
- W2063467319 cites W1614576580 @default.
- W2063467319 cites W1630411281 @default.
- W2063467319 cites W1641468872 @default.
- W2063467319 cites W1662189542 @default.
- W2063467319 cites W1967882942 @default.
- W2063467319 cites W1969785844 @default.
- W2063467319 cites W1971475788 @default.
- W2063467319 cites W1975783669 @default.
- W2063467319 cites W1978798502 @default.
- W2063467319 cites W1980528531 @default.
- W2063467319 cites W1981326638 @default.
- W2063467319 cites W1983277020 @default.
- W2063467319 cites W1987813798 @default.
- W2063467319 cites W1988156929 @default.
- W2063467319 cites W1988566023 @default.
- W2063467319 cites W1989730199 @default.
- W2063467319 cites W1989947835 @default.
- W2063467319 cites W1996401008 @default.
- W2063467319 cites W1997543717 @default.
- W2063467319 cites W1999157780 @default.
- W2063467319 cites W1999824494 @default.
- W2063467319 cites W2000236820 @default.
- W2063467319 cites W2002623358 @default.
- W2063467319 cites W2004863406 @default.
- W2063467319 cites W2005887351 @default.
- W2063467319 cites W2007231856 @default.
- W2063467319 cites W2009484032 @default.
- W2063467319 cites W2009556803 @default.
- W2063467319 cites W2011744245 @default.
- W2063467319 cites W2012390743 @default.
- W2063467319 cites W2012831549 @default.
- W2063467319 cites W2016397201 @default.
- W2063467319 cites W2024176341 @default.
- W2063467319 cites W2024251022 @default.
- W2063467319 cites W2026778256 @default.
- W2063467319 cites W2028400466 @default.
- W2063467319 cites W2028634080 @default.
- W2063467319 cites W2029582137 @default.
- W2063467319 cites W2031452885 @default.
- W2063467319 cites W2031513892 @default.
- W2063467319 cites W2034024825 @default.
- W2063467319 cites W2034368055 @default.
- W2063467319 cites W2037426608 @default.
- W2063467319 cites W2039531779 @default.
- W2063467319 cites W2040894153 @default.
- W2063467319 cites W2041380761 @default.
- W2063467319 cites W2043934481 @default.
- W2063467319 cites W2048009051 @default.
- W2063467319 cites W2050944466 @default.
- W2063467319 cites W2051538397 @default.
- W2063467319 cites W2051958752 @default.
- W2063467319 cites W2052607605 @default.
- W2063467319 cites W2056402816 @default.
- W2063467319 cites W2057126981 @default.
- W2063467319 cites W2058083313 @default.
- W2063467319 cites W2058484249 @default.
- W2063467319 cites W2062748636 @default.
- W2063467319 cites W2064511169 @default.
- W2063467319 cites W2069132844 @default.
- W2063467319 cites W2069325371 @default.
- W2063467319 cites W2071310612 @default.
- W2063467319 cites W2073140573 @default.
- W2063467319 cites W2073214715 @default.
- W2063467319 cites W2073466411 @default.
- W2063467319 cites W2077054785 @default.