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• W2063480372 abstract "The human OX-40 cell surface antigen is a CD4+ T cell activation marker that acts as a costimulatory receptor and is a member of the nerve growth factor receptor/tumor necrosis factor (TNF) receptor family. Using a soluble form of the receptor, the extracellular region fused with human immunoglobulin Fc, we expression cloned the human OX-40 ligand cDNA from a library derived from an activated B lymphoblastoid cell line MSAB. The encoded protein is identified as gp34, a type II transmembrane antigen previously known to be expressed only by human T cell lymphotropic virus 1-infected cells. We describe gp34 as a new member of the TNF family, and find that the recombinant ligand expressed in COS cells costimulates phorbol myristate acetate, phytohemagglutinin, and anti-CD3-induced CD4+ T cell proliferation." @default.
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• W2063480372 date "1994-08-01" @default.
• W2063480372 modified "2023-10-14" @default.
• W2063480372 title "Identification of a human OX-40 ligand, a costimulator of CD4+ T cells with homology to tumor necrosis factor." @default.
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• W2063480372 doi "https://doi.org/10.1084/jem.180.2.757" @default.
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