FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2063482014> ?p ?o ?g. }

• W2063482014 endingPage "e94691" @default.
• W2063482014 startingPage "e94691" @default.
• W2063482014 abstract "Tribbles homolog 3 (TRIB3) is a mammalian pseudokinase that is induced in neuronal cell cultures in response to cell death-inducing stresses, including neurotrophic factor deprivation. TRIB3 is an inhibitor of activating transcription factor 4 (ATF4), the central transcriptional regulator in the eukaryotic translation initiation factor 2α (eIF2α) phosphorylation pathway that is involved in the cellular stress response and behavioral processes. In this article, we study the expression of Trib3 in the mouse brain, characterize the brain morphology of mice with a genetic ablation of Trib3 and investigate whether Trib3 deficiency alters eIF2α-dependent cognitive abilities. Our data show that the consumption of a leucine-deficient diet induces Trib3 expression in the anterior piriform cortex, the brain region responsible for detecting essential amino acid intake imbalance. However, the aversive response to leucine-devoid diet does not differ in Trib3 knockout and wild type mice. Trib3 deletion also does not affect long-term spatial memory and reversal learning in the Morris water maze and auditory or contextual fear conditioning. During embryonic development, Trib3 expression increases in the brain and persists in the early postnatal stadium. Neuroanatomical characterization of mice lacking Trib3 revealed enlarged lateral ventricles. Thus, although the absence of Trib3 does not alter the eIF2α pathway-dependent cognitive functions of several areas of the brain, including the hippocampus, amygdala and anterior piriform cortex, Trib3 may serve a role in other central nervous system processes and molecular pathways." @default.
• W2063482014 created "2016-06-24" @default.
• W2063482014 creator A5017693223 @default.
• W2063482014 creator A5032406174 @default.
• W2063482014 creator A5037656140 @default.
• W2063482014 creator A5038506999 @default.
• W2063482014 creator A5048622515 @default.
• W2063482014 creator A5055256688 @default.
• W2063482014 creator A5062510004 @default.
• W2063482014 creator A5069283044 @default.
• W2063482014 creator A5082223134 @default.
• W2063482014 date "2014-04-14" @default.
• W2063482014 modified "2023-10-18" @default.
• W2063482014 title "Trib3 Is Developmentally and Nutritionally Regulated in the Brain but Is Dispensable for Spatial Memory, Fear Conditioning and Sensing of Amino Acid-Imbalanced Diet" @default.
• W2063482014 cites W1495108767 @default.
• W2063482014 cites W1964460778 @default.
• W2063482014 cites W1964526894 @default.
• W2063482014 cites W1972539689 @default.
• W2063482014 cites W1988575331 @default.
• W2063482014 cites W1990142715 @default.
• W2063482014 cites W1990720544 @default.
• W2063482014 cites W1991044118 @default.
• W2063482014 cites W2007857578 @default.
• W2063482014 cites W2013966205 @default.
• W2063482014 cites W2016122118 @default.
• W2063482014 cites W2017169966 @default.
• W2063482014 cites W2019542203 @default.
• W2063482014 cites W2021269348 @default.
• W2063482014 cites W2027281915 @default.
• W2063482014 cites W2027821655 @default.
• W2063482014 cites W2029186790 @default.
• W2063482014 cites W2040255749 @default.
• W2063482014 cites W2044675465 @default.
• W2063482014 cites W2045326722 @default.
• W2063482014 cites W2045755030 @default.
• W2063482014 cites W2046619643 @default.
• W2063482014 cites W2050733310 @default.
• W2063482014 cites W2053212444 @default.
• W2063482014 cites W2058333349 @default.
• W2063482014 cites W2067189757 @default.
• W2063482014 cites W2071038281 @default.
• W2063482014 cites W2071943997 @default.
• W2063482014 cites W2090952884 @default.
• W2063482014 cites W2127714237 @default.
• W2063482014 cites W2136729555 @default.
• W2063482014 cites W2147379012 @default.
• W2063482014 cites W2154391645 @default.
• W2063482014 cites W2154745705 @default.
• W2063482014 cites W2158553737 @default.
• W2063482014 cites W2160884130 @default.
• W2063482014 cites W2171089964 @default.
• W2063482014 cites W2410303565 @default.
• W2063482014 doi "https://doi.org/10.1371/journal.pone.0094691" @default.
• W2063482014 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3986210" @default.
• W2063482014 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24732777" @default.
• W2063482014 hasPublicationYear "2014" @default.
• W2063482014 type Work @default.
• W2063482014 sameAs 2063482014 @default.
• W2063482014 citedByCount "9" @default.
• W2063482014 countsByYear W20634820142015 @default.
• W2063482014 countsByYear W20634820142016 @default.
• W2063482014 countsByYear W20634820142017 @default.
• W2063482014 countsByYear W20634820142018 @default.
• W2063482014 countsByYear W20634820142019 @default.
• W2063482014 countsByYear W20634820142021 @default.
• W2063482014 crossrefType "journal-article" @default.
• W2063482014 hasAuthorship W2063482014A5017693223 @default.
• W2063482014 hasAuthorship W2063482014A5032406174 @default.
• W2063482014 hasAuthorship W2063482014A5037656140 @default.
• W2063482014 hasAuthorship W2063482014A5038506999 @default.
• W2063482014 hasAuthorship W2063482014A5048622515 @default.
• W2063482014 hasAuthorship W2063482014A5055256688 @default.
• W2063482014 hasAuthorship W2063482014A5062510004 @default.
• W2063482014 hasAuthorship W2063482014A5069283044 @default.
• W2063482014 hasAuthorship W2063482014A5082223134 @default.
• W2063482014 hasBestOaLocation W20634820141 @default.
• W2063482014 hasConcept C160539049 @default.
• W2063482014 hasConcept C16837860 @default.
• W2063482014 hasConcept C169760540 @default.
• W2063482014 hasConcept C170493617 @default.
• W2063482014 hasConcept C2779144063 @default.
• W2063482014 hasConcept C2780382662 @default.
• W2063482014 hasConcept C2781161787 @default.
• W2063482014 hasConcept C44752575 @default.
• W2063482014 hasConcept C4746552 @default.
• W2063482014 hasConcept C55493867 @default.
• W2063482014 hasConcept C86803240 @default.
• W2063482014 hasConcept C95444343 @default.
• W2063482014 hasConceptScore W2063482014C160539049 @default.
• W2063482014 hasConceptScore W2063482014C16837860 @default.
• W2063482014 hasConceptScore W2063482014C169760540 @default.
• W2063482014 hasConceptScore W2063482014C170493617 @default.
• W2063482014 hasConceptScore W2063482014C2779144063 @default.
• W2063482014 hasConceptScore W2063482014C2780382662 @default.
• W2063482014 hasConceptScore W2063482014C2781161787 @default.
• W2063482014 hasConceptScore W2063482014C44752575 @default.
• W2063482014 hasConceptScore W2063482014C4746552 @default.
• W2063482014 hasConceptScore W2063482014C55493867 @default.

• next