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• W2063485494 abstract "Os tumores neuroendócrinos pancreáticos (TNEPs) apresentam um espetro diversificado quanto à apresentação clínica, comportamento biológico, histopatologia e prognóstico. Distinguem-se os tumores funcionantes dos não funcionantes dependendo da capacidade de secreção hormonal. O objetivo deste trabalho foi analisar retrospetivamente os TNEPs acompanhados no Instituto Português de Oncologia de Lisboa, Francisco Gentil (IPOLFG) entre 2000-2011. Revisão de processos clínicos dos TNEPs com diagnóstico anatomo-patológico. A seleção foi feita a partir de bases de dados do Registo Oncológico Regional do Sul e dos Serviços de Anatomia Patológica e Endocrinologia do IPOLFG. Identificaram-se 44 TNEPs, 68,2% não funcionantes e 31,8% funcionantes (11 insulinomas e 3 gastrinomas). A maioria dos doentes era do sexo masculino (52,3%). A idade média na altura do diagnóstico foi de 55 anos (intervalo 31-83). A maioria dos TNEPs apresentou-se sintomática (79,5%), unifocal (70,5%) e bem diferenciada (63,6%). Doença locorregional e metastização estavam presentes em 61,4 e 56,8% respetivamente. Os exames de diagnóstico mais sensíveis foram a ressonância magnética (RM) e a ecoendoscopia. A principal terapêutica foi a cirúrgica. O tempo médio de seguimento foi de 32 meses (± 35; intervalo: 1 a 130 meses). A sobrevida média foi de 85 meses (± 11). Comparando os TNEPs não funcionantes e funcionantes, os primeiros apresentaram-se menos sintomáticos (73,3 vs 92,9%), e mais vezes com doença locorregional (73,3 vs 35,7%), metastização (70,0 vs 28,6%), índices proliferativos mais elevados e maior diâmetro tumoral (5,4 vs 2,9 cm). A sobrevida média foi mais elevada nos funcionantes (106 vs 72 meses). Dos fatores com impacto positivo no prognóstico destacam-se: funcionalidade, boa diferenciação histológica, ausência de angioinvasão, ausência de doença locorregional e metastização, índices proliferativos baixos. Como já observado noutras séries, a maioria dos TNEPs revelou-se não funcionante sendo o seu prognóstico pior do que os tumores funcionantes. Pancreatic neuroendocrine tumors (PNETs) have a broad spectrum of clinical behavior, histopathological characteristics and prognosis. Hormonal production distinguishes functional from nonfunctional tumours. The aim was to review the cases of PNETs diagnosed and/or followed, between 2000 and 2011, at Instituto Português de Oncologia de Lisboa, Francisco Gentil (IPOLFG). Data of clinical files of PNETs of the IPOLFG was analysed. Patients were identified through South Regional Cancer Registry and databases of IPOLFG's Pathology and Endocrinology Departments. 44 PNETs were identified, 68.2% nonfunctioning and 31.8% functioning (11 insulinomas and 3 gastrinomas). 52.3% of the cases were male. The median age at diagnosis was 55 years (range 31-83). The majority of all PNETs was symptomatic (79.5%), unifocal (70.5%) and well-differentiated (63.6%). Loco-regional disease and metastases were present in 61.4% and 56.8% of the cases, respectively. Magnetic resonance and endoscopic ultrasonography were the most sensitive exams. Surgery was the main treatment offered. Median follow-up time was 32 months (± 35; range 1 to 130 months) and median survival was 85 months (± 11). Comparison between nonfunctioning and functioning PNETs, revealed that patients in the former group were less symptomatic (73.3 vs 92.9%), presented more often loco-regional disease (73.3 vs 35.7%), metastases (70.0 vs 28.6%), higher proliferative indexes and tumoural diameter (5.4 vs 2.9 cm). Median survival was higher in functioning tumors (106 vs 72 months). Factors associated with a more favorable prognosis were: hormonal secretion; histological differentiation; absence of angioinvasion; absence of locorregional disease or metastization; low proliferative indexes. As observed in other series, the majority of PNETs were nonfunctional and the prognosis of these cases was worse than the prognosis of functional tumours." @default.
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• W2063485494 date "2013-01-01" @default.
• W2063485494 modified "2023-10-16" @default.
• W2063485494 title "Tumores neuroendócrinos pancreáticos: análise retrospetiva de 12 anos de experiência do Instituto Português de Oncologia de Lisboa" @default.
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• W2063485494 doi "https://doi.org/10.1016/j.rpedm.2013.05.001" @default.
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