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- W2063487122 abstract "The human serotonin 5-HT2B receptor, isolated from a human liver cDNA library, was transfected in COS-1 cells. Its pharmacological profile shows divergence with serotonin 5-HT2B receptors of other species. In particular, although strong correlation is observed between the human and the rat 5-HT2B receptor pharmacology, the correlation is almost as significant for the mouse 5-HT2B and the human 5-HT1D receptor agonists. The major sites of expression of its mRNA are in the human liver and kidney, with detectable expression in lung and heart. Therefore, this human 5-HT2B receptor could account for functions attributed to the peripheral 5-HT1D/5-HT2-like receptors, especially in the cardiovascular system. Thus, its detailed original pharmacology is of prime importance for therapeutic drug development." @default.
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- W2063487122 date "1994-10-03" @default.
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- W2063487122 title "The human serotonin 5-HT2B receptor: Pharmacological link between 5-HT2 and 5-HT1D receptors" @default.
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- W2063487122 doi "https://doi.org/10.1016/0014-5793(94)00968-6" @default.
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