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- W2063496162 abstract "3-phosphoinositide-dependent protein kinase-1 (PDK1) is a central mediator of cellular signaling between phosphoinositide-3 kinase and various intracellular serine/threonine kinases, including protein kinase B, p70 ribosomal S6 kinase, serum and glucocorticoid-inducible kinase, and protein kinase C. PDK1 activates members of the AGC family of protein kinases by phosphorylating serine/threonine residues in the activation loop. Here, we review the regulatory mechanisms of PDK1 and its roles in cancer. PDK1 is activated by autophosphorylation in the activation loop and other serine residues, as well as by phosphorylation of Tyr-9 and Tyr-373/376. Src appears to recognize PDK1 following tyrosine phosphorylation. The role of heat shock protein 90 in regulating PDK1 stability and PDK1-Src complex formation are also discussed. Furthermore, we summarize the subcellular distribution of PDK1. Finally, an important role for PDK1 in cancer chemotherapy is proposed. In conclusion, a better understanding of its molecular regulatory mechanisms in various signaling pathways will help to explain how PDK1 acts as an oncogenic kinase in various cancers, and will contribute to the development of novel cancer chemotherapies." @default.
- W2063496162 created "2016-06-24" @default.
- W2063496162 creator A5004102489 @default.
- W2063496162 creator A5023083703 @default.
- W2063496162 creator A5054534342 @default.
- W2063496162 date "2010-01-01" @default.
- W2063496162 modified "2023-10-12" @default.
- W2063496162 title "Multiple implications of 3-phosphoinositide-dependent protein kinase 1 in human cancer" @default.
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- W2063496162 doi "https://doi.org/10.4331/wjbc.v1.i8.239" @default.
- W2063496162 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3083972" @default.
- W2063496162 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21537480" @default.
- W2063496162 hasPublicationYear "2010" @default.
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