FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2063513426> ?p ?o ?g. }

• W2063513426 endingPage "19642" @default.
• W2063513426 startingPage "19637" @default.
• W2063513426 abstract "The transcription factor NFATp integrates multiple signal transduction pathways through coordinate binding with basic-region leucine zipper (bZIP) proteins and other transcription factors. The NFATp monomer, even in the absence of its activation domains, recruits bZIP proteins to canonical NFAT–bZIP composite DNA elements. By contrast, the NFATp dimer and its bZIP partner bind noncooperatively to the NFAT–bZIP element of the tumor necrosis factor ( TNF ) gene promoter. This observation raises the possibility that the function of the activation domains of NFATp is dimer-specific. Here, we determine the consensus DNA binding site of the NFATp dimer, describe monomer- and dimer-specific NFATp–DNA contact patterns, and demonstrate that NFATp dimerization and dimer-specific activation subdomains are required for transcriptional activation from the TNF NFAT–bZIP element. We also show that these NFATp subdomains interact with the coactivator CBP (CREB-binding protein), which is required for NFATp-dependent TNF gene transcription. Thus, the context-specific function of the activation domains of NFAT can be potentiated by DNA-directed dimerization." @default.
• W2063513426 created "2016-06-24" @default.
• W2063513426 creator A5027386160 @default.
• W2063513426 creator A5031613070 @default.
• W2063513426 creator A5043578923 @default.
• W2063513426 creator A5057700369 @default.
• W2063513426 creator A5061083848 @default.
• W2063513426 creator A5091116725 @default.
• W2063513426 creator A5091587653 @default.
• W2063513426 date "2008-12-16" @default.
• W2063513426 modified "2023-10-17" @default.
• W2063513426 title "A dimer-specific function of the transcription factor NFATp" @default.
• W2063513426 cites W1535444616 @default.
• W2063513426 cites W1569503463 @default.
• W2063513426 cites W1584114579 @default.
• W2063513426 cites W1607881510 @default.
• W2063513426 cites W1654064109 @default.
• W2063513426 cites W1847275787 @default.
• W2063513426 cites W1950580345 @default.
• W2063513426 cites W1976257926 @default.
• W2063513426 cites W1983089265 @default.
• W2063513426 cites W1986637935 @default.
• W2063513426 cites W1987676683 @default.
• W2063513426 cites W1994718301 @default.
• W2063513426 cites W1997657600 @default.
• W2063513426 cites W2000694165 @default.
• W2063513426 cites W2002485919 @default.
• W2063513426 cites W2018608979 @default.
• W2063513426 cites W2020952430 @default.
• W2063513426 cites W2021554725 @default.
• W2063513426 cites W2026370346 @default.
• W2063513426 cites W2035209826 @default.
• W2063513426 cites W2041113521 @default.
• W2063513426 cites W2042730534 @default.
• W2063513426 cites W2051237803 @default.
• W2063513426 cites W2059878047 @default.
• W2063513426 cites W2067011369 @default.
• W2063513426 cites W2069405394 @default.
• W2063513426 cites W2073580835 @default.
• W2063513426 cites W2082520295 @default.
• W2063513426 cites W2089307417 @default.
• W2063513426 cites W2095690101 @default.
• W2063513426 cites W2104582299 @default.
• W2063513426 cites W2105699218 @default.
• W2063513426 cites W2106800171 @default.
• W2063513426 cites W2107255820 @default.
• W2063513426 cites W2116015828 @default.
• W2063513426 cites W2116608195 @default.
• W2063513426 cites W2117989242 @default.
• W2063513426 cites W2121895544 @default.
• W2063513426 cites W2123898551 @default.
• W2063513426 cites W2138821254 @default.
• W2063513426 cites W2140124506 @default.
• W2063513426 cites W2140707292 @default.
• W2063513426 cites W2145069891 @default.
• W2063513426 cites W2146656738 @default.
• W2063513426 cites W2146963242 @default.
• W2063513426 cites W2148460689 @default.
• W2063513426 cites W2150290220 @default.
• W2063513426 cites W2151778247 @default.
• W2063513426 cites W2154658917 @default.
• W2063513426 cites W2157954582 @default.
• W2063513426 cites W2157973267 @default.
• W2063513426 cites W2161788277 @default.
• W2063513426 cites W2165626613 @default.
• W2063513426 cites W2169824225 @default.
• W2063513426 cites W2293706076 @default.
• W2063513426 cites W6965533 @default.
• W2063513426 doi "https://doi.org/10.1073/pnas.0810648105" @default.
• W2063513426 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2604938" @default.
• W2063513426 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19060202" @default.
• W2063513426 hasPublicationYear "2008" @default.
• W2063513426 type Work @default.
• W2063513426 sameAs 2063513426 @default.
• W2063513426 citedByCount "23" @default.
• W2063513426 countsByYear W20635134262012 @default.
• W2063513426 countsByYear W20635134262013 @default.
• W2063513426 countsByYear W20635134262014 @default.
• W2063513426 countsByYear W20635134262015 @default.
• W2063513426 countsByYear W20635134262017 @default.
• W2063513426 countsByYear W20635134262018 @default.
• W2063513426 countsByYear W20635134262020 @default.
• W2063513426 countsByYear W20635134262023 @default.
• W2063513426 crossrefType "journal-article" @default.
• W2063513426 hasAuthorship W2063513426A5027386160 @default.
• W2063513426 hasAuthorship W2063513426A5031613070 @default.
• W2063513426 hasAuthorship W2063513426A5043578923 @default.
• W2063513426 hasAuthorship W2063513426A5057700369 @default.
• W2063513426 hasAuthorship W2063513426A5061083848 @default.
• W2063513426 hasAuthorship W2063513426A5091116725 @default.
• W2063513426 hasAuthorship W2063513426A5091587653 @default.
• W2063513426 hasBestOaLocation W20635134261 @default.
• W2063513426 hasConcept C104317684 @default.
• W2063513426 hasConcept C138885662 @default.
• W2063513426 hasConcept C153911025 @default.
• W2063513426 hasConcept C156860981 @default.
• W2063513426 hasConcept C1629964 @default.
• W2063513426 hasConcept C178790620 @default.

• next