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- W2063515932 abstract "Abstract Isolated perfused canine and porcine livers were administered the choleretic hormones secretin, glucagon, and insulin to determine whether they would modify bile flow and composition in vitro as well as in vivo . Insulin did not produce volume or compositional changes in any of the doses tested, although decreases in plasma glucose and potassium were observed. These results support the hypothesis that insulin choleresis is mediated by extrahepatic processes, such as cholinergic innervation. Glucagon (0.1 mg/20 min) induced a choleresis in the porcine livers; however, the composition of the bile did not reflect the chloride enrichment seen in vivo . Glucagon-induced increases in pyruvate consumption, glucose levels, and potassium were accompanied by decreases in portal venous pressure. Secretin promoted a bicarbonate-enriched choleresis in both species; chloride concentrations were significantly decreased as compared to control and in vivo values. Thus, all of the hormones tested exhibited different choleretic behavior in vitro than they did in vivo . These results support the theory that glucagon and secretin act hepatically to produce choleresis but that the composition of the bile may be modified by extrahepatic factors. Insulin choleresis is apparently mediated exclusively by extrahepatic means." @default.
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- W2063515932 date "1979-06-01" @default.
- W2063515932 modified "2023-09-23" @default.
- W2063515932 title "Secretin-, glucagon-, and insulin-induced effects on bile flow and metabolism of isolated perfused canine and porcine liver" @default.
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- W2063515932 doi "https://doi.org/10.1016/0022-4804(79)90064-7" @default.
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